نتایج جستجو برای: clostridium difficile
تعداد نتایج: 24557 فیلتر نتایج به سال:
BACKGROUND We identified 12 patients with Clostridium difficile infection between July 2011 and March 2012 from whom an unusual C. difficile strain was isolated. This strain had a single-nucleotide deletion of the tcdC gene at position 117 and binary toxin genes, which are characteristic of the hypervirulent ribotype (RT) 027 strain. METHODS A retrospective cohort study of 12 patients infecte...
Cytotoxicity of Clostridium difficile toxin A for human colonic and pancreatic carcinoma cell lines.
The use of bacterial exotoxins may constitute novel adjuncts to treatment of gastrointestinal tract malignancies. Clostridium difficile toxin A was evaluated for its cytotoxic effect in vitro on 24 human cell lines and strains including carcinomas of the colon, pancreas, prostate, lung, breast, and lymphoid malignancies, as well as nonmalignant tissues. All nine colon and five pancreas cell lin...
Clostridium butyricum is one of the species frequently present in patients' stool samples. However, the identification of this species is sometimes difficult. Here, we present the draft genome of Clostridium butyricum NOR 33234, which was isolated from a patient with suspected Clostridium difficile infection-associated diarrhea and resembles Clostridium clostridioforme in biochemical tests.
Clostridium Difficile Toxin A+B Rapid Test provides a procedure for a qualitative detection of Clostridium difficile toxin A (TcdA) and toxin B (TcdB) in two separate bands. A positive band of either toxin is a sign of an underlying Clostridium difficile infection (CDI), which should attract the attention of the physician. Samples used are liquid or semi-liquid human stool samples. Care must be...
METHODS We compared time from hospital admission to death in a probability sample of 100 Clostridium difficile infected cases and a probability sample of 98 non-cases admitted to an English teaching hospital between 2005 and 2007 with follow up in the UK national death register using survival analysis. RESULTS Clostridium difficile infection was associated with a 50% increased risk of death (...
effectiveness of fecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection. The aim of this study is to evaluate the cost-effectiveness of fecal microbiota transplantation compared with vancomycin for the treatment of Clostridium difficile infection in Australia. Methods: A Markov model was developed to compare the cost-effectiveness of fecal microbiota tra...
OBJECTIVE To estimate prevalence and determine association between antimicrobia resistance and toxin gene profile of Clostridium difficile in commercial pigs at the preharvest food-safety level. ANIMALS 68 sows and 251 young pigs from 5 farms in North Carolina and 3 in Ohio. PROCEDURES Fecal samples were collected from sows (8/farm) and matched young pigs (32/farm) at farrowing and again at...
Background: Reduced susceptibility of Clostridium difficile to antibiotics is problematic in clinical settings. There is new evidence indicating the cotransfer of toxin-encoding genes and conjugative transposons encoding resistance to antibiotics among different C. difficile strains. To analyze this association, in the current study, we evaluated the frequency of toxigenic C. difficile among th...
We tested the effectiveness of disinfectants and wipe methods against Clostridium difficile spores. Wiping with nonsporicidal agents (physical removal) was effective in removing more than 2.9 log(10) C. difficile spores. Wiping with sporicidal agents eliminated more than 3.90 log(10) C. difficile spores (physical removal and/or inactivation). Spraying with a sporicide eliminated more than 3.44 ...
Clostridium difficile remains the major cause of nosocomial diarrhea. Reports on impaired susceptibility of C. difficile to metronidazole and vancomycin and frequent relapses of patients after therapy necessitate the search for new substances. With this study, the activity of OPT-80, a new macrocycle, against 207 C. difficile strains and against other obligately anaerobic bacteria was tested. O...
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