background: evaluating the significance and the effects of plant-derived drugs on laboratory animal’s fertility was recognized. there was antioxidant activity reported from heracleum persicum (golpar).objective: current study aims to study the antioxidant effect of golpar extracts on sperm parameters and chromatin quality in mice.materials and methods: eighteen adult male mice were divided to 3...

Background: Selection of human spermatozoa prior to assisted reproduction is currently based on motility and morphology. Recently, Zeta method has been introduced for normal sperm selection based on sperm surface charges. In addition, one of the features of apoptosis is the externalization of phosphatidylserine (PS), which are normally present on the inner leaflet of the sperm plasma membrane. ...

background: diabetes mellitus (dm), primary or idiopathic is a chronic disorder of the carbohydrate, lipid and protein metabolism. dm may impact male reproductive function at several levels. it is shown that dm has detrimental effects on sperm parameters in human and experimental animals. objective: the aim of this study was to observe the effects of diabetes on sperm parameters (viability, cou...

many biological factors affect radiosensitivity. in this study, radiosensitivity among the different blood groups was investigated. peripheral blood sample of 95 healthy people were divided into two parts. one part was irradiated with 2 gy co-60 gamma rays and the second one was considered as control. then all the samples were studied by cytokinesis-blocked micronucleus assay (cbmn assay). our ...

cancer is a major cause of death worldwide and causes serious problems in human life. it is developed by uncontrolled growth of a cell or a group of cells. there are many difficulties in treatment of cancer and many researchers are involved in investigating for effective drugs to treat the disease. caryophyllaceae is a large family of about 86 genera and 2200 herbaceous or subshrub species. the...

background and objective: gastric cancer is the fourth common and the second deadliest cancer worldwide, which the major causes of its prevalence are genetic factors and the lifestyle, such as eating fast foods, physical inactivity, environmental pollution, and other natural factors. method: this research was performed in human and animal cell bank of iranian biological resource center, and cyt...

background: despite the wide range of applications, there is a serious lack of information on the impact of the nanoparticles on human health and the environment. the present study was done to determine the range of dangerous concentrations of iron oxide nanoparticle and their effects on mouse embryonic stem cells. methods: iron oxide nanoparticles with less than 20 nanometers diameter were enc...

introduction: cell culture is a process in which the cells ware isolated from original tissue, dispersed in liquid media and then placed in culture plate where the cells adhere together and propagate. today, this method is used for assessment of cell toxicity, its mechanisms and effect of different compounds on intracellular components. methods: clonogenic assay was used for assessment of cell ...

background leptospirosis is a systemic infectious disease caused by pathogenic bacteria belonging to the species of leptospira, it is considered to be the most common zoonosis in the world. this is a serious and sometimes fatal infection which is transmitted from animals to humans by entering the digestive tract or mucosal membrane. within the initial 10-12 day period, the patient may experienc...