BACKGROUND Cognitive remediation (CR) has shown significant promise in addressing the cognitive deficits that accompany serious mental illness. However, this intervention does not appear to completely ameliorate the cognitive deficits that accompany these illnesses. D-cycloserine (DCS), an NMDA receptor partial agonist, has been shown to enhance the therapeutic benefits of learning-based psycho...

UNLABELLED BACKGROUND/STUDY CONTEXT: We demonstrate that observer-rated factor structure of personality in centenarians is congruent with the normative structure. Prevalence of cognitive impairment, which has previously been linked to changes in personality in younger samples, is high in this age group, requiring observer ratings to obtain valid data in a population-based context. Likewise, the...

BACKGROUND Large differences in substance use between educational levels originate at a young age, but there is limited evidence explaining these inequalities. The aim of this study was to test whether a) smoking and binge drinking are associated with lower levels of self-control and cognitive functioning, and b) associations between educational track and smoking and binge drinking, respectivel...

OBJECTIVES Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression. METHODS Data were ...

Background and Objectives: A relationship has been found between cognition and functioning in patients with schizophrenia. Our objective was to study the relationship between the cognitive domains assessed by the MATRICS Consensus Cognitive Battery (MCCB), and functioning as evaluated using the functioning subscale of the Global Assessment of Functioning scale (GAF-f). Methods: A sample of 83 c...

OBJECTIVES. To explore the relationship between cognitive functions, social functioning, and psychopathology in schizophrenia. METHODS. Patients diagnosed with schizophrenia, according to the ICD-10 criteria, were enrolled from the Department of Psychiatry of 2 postgraduate hospitals in Kolkata, India. The Positive and Negative Syndrome Scale for Schizophrenia, Schizophrenia Research Foundation...

This paper investigates the impact of family income, material deprivation, maternal socioeconomic status and child-rearing behaviour on an indicator of cognitive functioning, using data for children aged 6 to 17 years from the British National Child Development Study. There are large differences in cognitive functioning by income, before differences in other socio-economic indicators had been c...

Objectives Inconsistent results are found in the involvement of the Hypothalamus-Pituitary-Adrenal (HPA)-axis in cognitive functioning. This study examined the association between various saliva cortisol measures and cognitive functioning in older persons with and without a depressive disorder. Methods Cross-sectional data on 328 depressed and 119 non-depressed older adults between 60-93 years ...

OBJECTIVE Findings in the literature are inconsistent on the impact of congenital heart disease (CHD) on the psychological and cognitive functioning of children and adolescents. The aim of the present study was to systematically review this empirical body of literature. METHODS We conducted a meta-analysis to review studies on behavior problems and cognitive functioning in CHD. RESULTS Only...