نتایج جستجو برای: colchicine col
تعداد نتایج: 9796 فیلتر نتایج به سال:
Tubulin isotypes are found to play an important role in regulating microtubule dynamics. The isotype composition is also thought to contribute in the development of drug resistance as tubulin isotypes show differential binding affinities for various anti-cancer agents. Tubulin isotypes αβII, αβIII and αβIV show differential binding affinity for colchicine. However, the origin of differential bi...
BACKGROUND Gloriosa superba produces an array of alkaloids including colchicine, a compound of interest in the treatment of various diseases. The tuber of Gloriosa superba is a rich source of colchicine which has shown anti-gout, anti-inflammatory, and anti-tumor activity. However, this promising compound remains expensive and Gloriosa superba is such a good source in global scale. Increase in ...
This research aimed to induce in vitro and identify polyploidy plantlets of Porang (Amorphophallus muelleri Blume) after colchicine treatment. In shoot base explants porang were cultured on MS medium containing different concentrations 30, 60, 90, 120 mg/l for four weeks while the control was without colchicine. After weeks, all treated untreated multiplied regenerated into plantlets. Flow cyto...
COL104 Baroque Rome This interdisciplinary history seminar for first-year students focuses on Europe's most famous capital city between 1550 and 1650, a period when Rome was a symbol of religious zeal, artistic creativity, and intellectual repression. We will explore these contradictions and their impact on cultural innovation by taking a close look at daily life in early modern Rome and at the...
OBJECTIVE To review the evidence for the efficacy and safety of colchicine in children with pericarditis. DESIGN Systematic review. SEARCH STRATEGY The following databases were searched for studies about colchicine in children with pericarditis (June 2015): Cochrane Central, Medline, EMBASE and LILACS. ELIGIBILITY CRITERIA All observational and experimental studies on humans with any leng...
OBJECTIVE To determine whether or not the use of colchicine decreases the risk of amyloidosis among Armenian patients with familial Mediterranean fever (FMF). SUBJECTS AND METHODS The study included 99 Armenian patients from the Center of Medical Genetics database with genetically ascertained FMF; 33 had renal amyloidosis and 66 were randomly selected control patients without renal amyloidosi...
The interaction of tubulin-microtubule poison complexes with anti-tubulin antisera has been investigated using radioimmunoassay. The binding of the major antiserum used in this study to tubulin does not interfere with the binding of colchicine to the tubulin or affect the decay of the colchicine-binding activity of the tubulin. Conversely, if colchicine is incubated with the tubulin, forming tu...
background: postoperative peritoneal adhesion bands are one of the most common complications caused by foreign material. objective: to investigate the effect of colchicine on talc-induced peritoneal adhesion bands. method: adhesion bands were induced in 30 short hair england guinea pigs by introduction of talc-saline solution (10 ml, 10%) into the peritoneal cavity. afterwards, the pigs we...
colchicine, a potent neurotoxin derived from plants, has been recently introduced as a degenerative toxin of small pyramidal cells in the cortical area 1 of the hippocampus (ca1). in this study, the effect of the alkaloid in ca1 on the behaviors in the conditioning task was measured. injections of colchicine (1,5 μg/rat, intra-ca1) was performed in the male wistar rats, while the animals were s...
OBJECTIVE The collagen subtypes I (Col I) and III (Col III) are essential components of the cardiac extracellular matrix (ECM) maintaining the functional integrity of the heart. Histological, immunohistological, and biochemical studies, however, demonstrate characteristical changes of the ECM in dilated cardiomyopathy, myocarditis, ischemic cardiomyopathy, and hypertensive heart disease. METH...
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