PURPOSE BARD1 is a BRCA1-binding partner with tumor suppressive properties. Aberrant splice variants of BARD1 have been detected in various cancers, and it has been postulated that the presence of some splice variants is cancer specific. This is the first study assessing BARD1 expression patterns and correlation with clinical outcome in colon cancer. EXPERIMENTAL DESIGN We analyzed colon canc...

MYH9 (myosin, heavy chain 9, non-muscle) as a gene encodes NM II-A (non-muscle II-A) protein, exists primarily in the cytoplasm. MYH9 consists of 2 mysoin heavy chains with a relative molecular mass of 230 kDa. Previous studies have shown that MYH9 is involved in a number of diseases, including cancer. However, the exact role of MYH9 in colon cancer is still unclear. Therefore, we used a tissue...

there is a good literature confirming the effects of social capital on different health domains. the increase in different types of cancer has caused scientists to encounter a number of issues regarding the reasons of affliction by this disease. the aim of this empirical research was to study the causal aspects of social capital of iranian patients with cancer.the study was a causal-comparative...

background: bax and bcl-2 are the major members of bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate. methods: in this study, the relative level of mrna expression of bax and bcl-2 genes was deter...

BACKGROUND Although data on the association of physical activity and colon cancer risk is convincing, little research has examined whether change in physical activity alters risk of cancer incidence and mortality. METHODS We examined the association of 10- and 15-year change in physical activity with risk of colon cancer incidence and mortality in the Cancer Prevention Study II. Endpoints wer...

BACKGROUND As a disease with extremely complex molecular mechanisms, many deregulated miRNAs have been identified in colon cancer. Few studies have been performed by using Ingenuity Pathways Analysis (IPA) to predict miRNAs specifically expressed in colon cancer. METHODS A characteristic microRNA-target network of colon cancer was explored using IPA. Then the clinical significance of miR-19b-...

Colon cancer development is closely related to inflammation. Thus, we conducted the present investigation to study the effects of IL-35 (Interleukin 35), a newly identified anti-inflammatory factor, on colon cancer development. We first evaluated the IL-35 expression in 186 pairs of colon cancer samples and paired adjacent normal tissues by qPCR, ELISA (Enzyme-linked immunoassay) and tissue mic...

Abstract The understanding and explanation of inflammation-dysplasia-cancer sequence is challenging. gut microbiota an important factor for the intestine wall. changes in bacteria quality and/or quantity (dysbiosis) may begin colon inflammation. This paper reviewed microbiome risk factors which lead to cancer.

The occurrence and development of colon cancer is closely related to inflammation. Thus, we conducted the present retrospective study to investigate the effects of IL-37 (Interleukin 37), a newly identified anti-inflammatory factor, on colon cancer development. We first evaluated the IL-37 expression in 186 pairs of colon cancer samples and their adjacent normal mucosa by real-time PCR, ELISA (...

Micro RNAs (miRNAs) are important regulators involved in various physical and pathological processes, including cancer. The miRNA-302 family has been documented as playing a critical role in carcinogenesis. In this study, we investigated the role of miRNA-302a in colon cancer. MiRNA-302a expression was detected in 44 colon cancer tissues and 10 normal colon tissues, and their clinicopathologica...