Context: Colorectal carcinomas (CRC) in Africans tend to occur at an earlier age and have unique clinicopathologic as well as putatively distinctive molecular characteristics. We recently undertook a study of the microsatellite instability (MSI) analysis of a cohort of colectomies in our practice to examine this issue further. Methods: Fifty-five (55) colectomies done for colorectal carcinoma w...

Anthranoid-containing laxatives--aloe, cascara, frangula, and rheum--may play a role in colorectal cancer. This risk is particularly important in view of the wide abuse of self administered laxatives for chronic constipation. There are data on the genotoxic potential of anthranoids and there is evidence of a tumourigenic potential in rodents. A case report and clinical-epidemiological studies h...

Background & Objective: The current approaches to reduce the risk of colorectal carcinoma are through the detection and removal of the precursor lesion” adenomatous polyps”. The study was conducted to evaluate the immunohistochemical expression of p53 and bcl-2 in colorectal adenomas and carcinomas. Patients and Methods: A total of 86 cases, 33 colorectal adenomas, 33 colorectal adenocarcinomas...

BACKGROUND Colorectal carcinoma is thought to be rare among children and young adults among whom presentation is usually at a late stage with poor prognosis. OBJECTIVE To review the demography, clinical presentation, morphology, and pathological stage of cases of colorectal carcinomas diagnosed in the children and adults. METHODS This was a retrospective review of cases of histologically di...

AIMS Endonuclease G (EndoG) is a mitochondrial protein that plays a role in DNA fragmentation during apoptosis. In addition, EndoG plays a role in cell proliferation and survival. It may be important to identify EndoG protein expression to predict its function in human cancers. The aim of this study was to explore whether alteration of EndoG expression might be a characteristic of colorectal or...

AIM The aim of this paper is to examine COX-2 expression in human recurrent colorectal carcinoma tissues using immunohistochemistry and quantative real-time PCR (qPCR). METHODS Colon and rectal specimens were obtained from 26 patients with recurrent colorectal carcinomas. We examined COX-2 expression in human recurrent colorectal carcinoma tissues using immunohistochemistry and quantative rea...

nloaded mutations cause activation of Wnt/β-catenin signaling, which invariably leads to colorectal cancer. rly, overexpressed Dvl proteins are potent activators of β-catenin signaling. Screening a large tissue array of different staged colorectal tumors by immunohistochemistry, we found that Dvl2 has a strong cy to be overexpressed in colorectal adenomas and carcinomas, in parallel to nuclear ...