Telomere shortening and telomerase activation occur frequently in cases of colorectal carcinoma. In this study, we correlated the clinicopathological parameters with the telomere length in colorectal carcinomas, colonic polyps, and normal colonic tissues. We also investigated whether the telomere length changes reflect the biologic behavior of tumors and different modes of tumor development. Te...

BACKGROUND Colon cancer is a leading cause of morbidity and mortality in developed countries. The early detection of colorectal cancer using screening programs is important for managing early-stage colorectal cancers and polyps. Modalities that allow examination of the entire colon are conventional colonoscopy, double contrast barium enema examination and multi-detector computed tomography (MDC...

Abstract The narrow-band imaging (NBI) International Colorectal Endoscopic (NICE) classification is based on pictures of colon polyps viewed through a spectrum. categorisation utilises staining, surface structure, and vascular patterns to differentiate between hyperplastic adenomatous polyps. It known that accuracy the NICE for colorectal varies depending localisation in colon.The aim this stud...

Recent studies have suggested that hyperplastic polyps may be benign precursor lesions for a distinct subset of colorectal tumors. We conducted a clinic-based case-control study to evaluate risk factors for hyperplastic polyps. Cases with hyperplastic polyps (n = 219), adenomas (n = 437), and both types of polyps (n = 138), along with colonoscopy-negative controls (n = 708), were identified at ...

Attenuated familial polyposis (AFAP) is a subset of familial adenomatous polyposis (FAP) that has a relatively benign disease course. AFAP is characterized by no more than 100 colorectal polyps and has a tendency toward rectal sparing, a 20–25-year delay in the onset of adenomatosis and bowel symptoms, a 10–15-year delay in the development of colorectal cancer, and death caused by colorectal ca...

In the present study, we investigated the prognostic and diagnostic significance of -catenin nuclear immunostaining in 60 specimens of normal colorectal tissue; 180 specimens of colorectal polyps, adenomas, and carcinomas; and 40 specimens from patients with the simultaneous occurrence of polyps, adenomas, and carcinomas. Additional specimens from 59 patients with colorectal carcinoma and 14 pa...

The first-degree relatives of patients affected by colorectal cancer, who do not belong to familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer families, have a doubled risk of developing tumors of the large intestine. We have previously demonstrated that subjects with a single first-degree relative (SFDR) with colon cancer have a doubled risk for developing colorectal a...

BACKGROUND The relationship between plasma gastrin levels and colorectal cancer is controversial. When confounding factors which increase plasma gastrin levels are taken into account, it has been shown that gastrin levels are not elevated in patients with colorectal cancer. However, these studies only measured amidated gastrin. Total gastrin (which includes unprocessed, partially processed, and...

Many public health organizations, including the American Cancer Society, recommend colorectal carcinoma screening for all average risk adults beginning at the age of 50 years. Colorectal cancers are known to develop from precursor adenomatous polyps that progress from small to large size and from dysplasia to cancer over the course of many years. Despite the potential for prevention, patient co...

The principal aim of this study is to investigate the scattering coefficient of colorectal polyp tissues using an optical coherence tomography (OCT) technique. It combines the existing scattering coefficient model and spectral domain OCT to achieve method of early diagnosis of colorectal polyp in hospitals. Seventeen patients were studied, and a total of 1456 data points were extracted by curve...