An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken desi...

Bilayer floating-bioadhesive drug delivery systems exhibiting a unique combination of floatation and bioadhesion to prolong gastric residence time were developed. Hydroxypropyl methylcellulose and sodium bicarbonate were added such that when immersed in 0.1N HCl, the tablet expands and rises to the surface and famotidine is gradually released without interference from gas bubbles. Effect of dif...

Compliance with regular medicine taking has been assessed in 81 patients, aged 65 and over, living at home. Interview assessment, home tablet count, and retrospective review of general practice prescription record cards provided three indices of compliance.Deviation by more than 10 per cent from absolute adherence to the prescription was found in 53 per cent of all tablet counts and was signifi...

background: the poisoning is mostly due to suicide and is observed in younger age groups. the systemic manifestations of alp poisoning are common but pernicious manifestations of them are cardiotoxicity, shock, and ards. the clinical hallmark of cardiotoxicity is arrhythmia. the aim of this study was to investigate cardiac arrhythmias in patients poisoned with alp who were admitted to razi hosp...

the objective of this work was to develop and evaluate the levofloxacin hemihydrate floating formulations (f1-f9). selection of optimized batch was done by model dependent approach and novel mathematical approach. f1-f9 batches were prepared by direct compression method using gelucire 43/01 (hydrophobic) and hydroxypropylmethylcellulose (hydrophilic) polymer in different ratios. the floating ta...

in the current study, floating dosage form containing acyclovir was developed to increase its oral bioavailability. effervescent floating tablets containing 200 mg acyclovir were prepared by direct compression method with three different rate controlling polymers including hydroxypropyl methylcellulose k4m, carbapol 934, and polyvinylpyrrolidone. optimized formulation showed good floating prope...