キーワード:創薬標的,リスク遺伝子,遺伝子改変動物,エンドフェノタイプ,病態改善 アステラス製薬株式会社 研究本部 薬理研究所 神経科学研究室(〒305 -0841 つくば市御幸が丘 21) CNS, Astellas Research Institute of America LLC, 8045 Lamon Ave, Skokie, IL 60077, USA E-mail: [email protected] 原稿受領日:2012 年 5 月 23 日,依頼原稿 Title: Approach for identifying novel drug targets of schizophrenia Author: Katsunori Tajinda, Shinichi Miyake, Mitsuyuki “Mickey” Matsumoto 要約:統合失調...

1031 ISSN 1743-5889 10.2217/NNM.13.95 © 2013 Future Medicine Ltd Nanomedicine (2013) 8(7), 1031–1033 “What is needed in the field is a set of nanoparticle physicochemical characterization and biological evaluation criteria that allow not only the author, but also the reader, to fully understand the mechanism of activity, interpret experimental data and bring standardization that is required for...

Peptide dendrimers are a novel type of macromolecules with precise structure, which can be used as drug target vector and controlled-release carrier. So it is valuable to study. In this paper, novel peptide dendrimers PDL-GB2 and PDL-G2 were prepared according to divergent procedure with four-orientation molecule as the core and L-lysine as the branch unit. And the structures were identified by...

Hydrogels have been shown to be very useful in the field of drug delivery due to their high biocompatibility and ability to sustain delivery. Therefore, the tuning of their properties should be the focus of study to optimise their potential. Hydrogels have been generally limited to the delivery of hydrophilic drugs. However, as many of the new drugs coming to market are hydrophobic in nature, n...

We reported in this study a versatile method to prepare multi-responsive supramolecular hydrogels for drug delivery application.

Over the past several years, great advances have been made towards novel drug delivery systems. The phenomena of interpolymer interactions and formation of polyelectrolyte complexes have been the focus of intensive fundamental and applied research. Interpolyelectrolyte complexes combine unique physicochemical properties with high biocompatibility. Studies have been carried out on many different...

Paul Curley1, Neill J Liptrott1,2 & Andrew Owen*,1,2 1Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK 2European Nanomedicine Characterisation Laboratory, Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK * Author for correspondence: Tel.: +44 0 ...