BACKGROUND C-peptide measurement has been widely used as a marker of insulin secretion in patients with diabetes. We assessed the comparability of C-peptide results obtained with different methods and by different laboratories and determined whether C-peptide results could be harmonized by normalization with a WHO reference reagent or with plasma. METHODS We sent 16 different heparin plasma s...

Determining biosimilarity involves a comprehensive exercise with a focus on determining the comparability of the molecular characteristics and preclinical profile of the biosimilar and reference product, such that there is less need for extensive clinical testing to assure comparability of clinical outcomes. Three anti-TNF biosimilar agents are approved for patients with rheumatic diseases in t...

In some testing applications, ComputerBased Test (CBT) delivery is gaining popularity over the traditional PaperPencil-Test (PPT) delivery due to the several potential advantages that it offers, such as immediate scoring and reporting of results, more flexible test scheduling, the opportunity to include innovative item formats that are made possible by the use of technology, and reduced costs o...

Dushnik and Miller defined the dimension of a partial order P as the minimum number of linear orders whose intersection is P. Ken Bogart asked if the dimension of a partial order is an invariant of the associated comparability graph. In this paper we answer Bogart's question in the affirmative. The proof involves a characterization of the class of comparability graphs defined by Aigner and Prin...

This study investigated the differences between the Standard and Short forms of MicroCog by comparing Domain scores for a clinical sample of 351 substance abusers which gave a significant difference between scores on the Spatial Processing Domain. Implications for research and clinical use are discussed.