MASP-3 was discovered 15 years ago as the third mannan-binding lectin (MBL)-associated serine protease of the complement lectin pathway. Lacking any verified substrate its role remained ambiguous. MASP-3 was shown to compete with a key lectin pathway enzyme MASP-2 for MBL binding, and was therefore considered to be a negative complement regulator. Later, knock-out mice experiments suggested tha...

By work of W. Thurston, knots and links in the 3-sphere are known to either be torus links, or contain an essential their complement, hyperbolic, which case a unique hyperbolic volume can calculated for complement. We employ construction Turaev associate family 3-manifolds finite any classical virtual link, even if non-hyperbolic. These turn used define is minimal among all associated via this ...

OBJECTIVE To see the response of steroid and cyclophosphamide if membranoproliferative glomerulonephritis is classified by pattern of immune and complement deposits. METHODS The retrospective study was conducted at The Kidney Centre, Karachi, and comprised patients treated for membranoproliferative glomerulonephritis between 1996 and 2013. Records of patients who were not treated with immunos...

Complement provides a key immunologic defense against invading pathogens; thus, a clear understanding of the interactions between cytomegalovirus (CMV) and complement may permit the development of strategies to enhance CMV neutralization. In the presence of specific anti-CMV antibodies, complement enhanced the neutralizing ability of serum by 2- to 3-fold. However, in the absence of specific an...

Requirements for complement and antibody in neutrophil-mediated killing of serotype IV and V group B streptococci were investigated. Neutrophils from adults were tested in an opsonophagocytic assay with sera from healthy adults, healthy newborns, and hypogammaglobulinemic, agammaglobulinemic, and C4-deficient patients. For all serum sources, the bactericidal index for both serotypes exceeded 84...

The frequency of complement deficiency in 176 of 7,732 patients with meningococcal disease in the Netherlands from 1959 through 1992 was assessed. Complement deficiency was found in six patients (3%): 3 (7%) of the patients with Neisseria meningitidis serogroup C disease, 1 (2%) of the patients with N. meningitidis serogroup A disease, and 2 (33%) of the patients with infections due to uncommon...

We have found that complement is activated during blood coagulat ion (1). This activation was characterized by the development of ultrastructural lesions on the platelet surface subsequent to physiologic clotting. The appearance of the lesions was dependent on the presence of thrombin and of C3. In further studies, the role of complement in thrombin-media ted platelet function was investigated ...

1. The complement 3 (C3) phenotype distribution in 112 patients with essential hypertension was compared with the distribution of 316 normotensive control subjects. 2. A significant increased frequency of the C3F-gene was found among the patients (0.2637 vs 0.1721, P = 0.0031), indicating an association between the C3F-gene and essential hypertension. 3. The relative risk of essential hypertens...

The relationship of anaphylatoxin to the complement system has received increasing attention in the past few years. Osier et al. (1) observed a positive correlation between the activity of the third component of complement in rat serum and the capacity of the serum to generate anaphylatoxin. Recently, a direct relation of anaphylatoxin with the complement system has been demonstrated through th...