The immunological study of the Shope papilloma virus (1) has exceptional interest, for the virus causes enduring, proliferative growths that have the character of tumors (2). In the work now to be reported a complement fixation reaction has been used in addition to the neutralization test previously employed (3). Special attention has been paid to the relation of the virus and the complement-bi...

The literature concerning various serological reactions in malaria in man has been well reviewed (1). According tothis review, attempts to obtain a specific complement fixation reaction with sera from human beings infected by Plasmodium vivax or by Plasmodium falciparum have led in the past to inconclusive results because no sensitive, specific, and easily standardized antigen was available. Du...

The Italian workers D'Alessandro, Oddo, Comes, and Dardanoni (1949) and D'Alessandro and Dardanoni (1953) described the isolation of four serologically active components of Reiter's treponeme. These contributions represent milestones in the sero-diagnosis of syphilis since they were the initial systematic investigations into the serological components of treponemes. One of the components was co...

A quantitative complement fixation test with influenza immune sera and virus antigens obtained from allantoic fluid is described. The method utilizes a photoelectric densitometer which provides a simple, objective, and accurate determination of the hemolytic reaction. The enhancement of the hemolytic activity of complement in the presence of serum or allantoic fluid necessitates a preliminary t...

Hitherto in poliomyelitis complement-fixation tests on human sera the antigenic material has usually been derived from tissue cultures of polio viruses. Despite high infectivity titres, antigens from this source are weak in capacity to fix complement (Selzer, 1958). Concentration of tissue culture antigens improves the complement-fixing power but frequently produces anti-complementary effects. ...

After material has been produced for use as an antigen in a complement fixation test it is necessary to find out if the finished product has any complement-fixing ability in the presence of a serum containing a suitable antibody. Moreover, the proposed antigen must not have any undue anticomplementary property, and the " gap" between its anticomplementary titre and its complement fixing titre m...

Clinical and epidemiological observations on 87 cases of donovanosis seen at Port Moresby General Hospital are presented, with detailed reports of three cases in which the disease was more severe. The circumstances of infection described were consistent with venereal transmission. Chloramphenicol and gentamicin were effective in curing the disease, while streptomycin was found to be ineffective...

A trial of antigen prepared from Ascaris lumbricoides in the complement-fixation test for pulmonary tropical eosinophilia and for filariasis is described. No significant difference was observed between this antigen and that prepared from Dirofilaria immitis.

The recent outbreaks of human fascioliasis in Britain provided the opportunity for employing the double diffusion precipitin test in the diagnosis of this disease. In sensitivity and specificity this test appears to equal the complement-fixation test and has the advantages of simplicity and speed in its performance.

The technique of complement fixation test as a measure for the serological diagnosis of neurotropic virus infections was first put in practice by Casals and Palacios (1) in the year 1941, and confirmed of its practical diagnostic value by numerous follow-ups made after it. In spite of repeated attempts, the application of this technique for the diagnosis of poliomyelitis had not been successful...