In the signal attenuation rat model of obsessive-compulsive disorder (OCD), lever-pressing for food is followed by the presentation of a compound stimulus which serves as a feedback cue. This feedback is later attenuated by repeated presentations of the stimulus without food (without the rat emitting the lever-press response). In the next stage, lever-pressing is assessed under extinction condi...

OBJECTIVE To test the association between Tourette syndrome (TS) and genetic variants in genomic loci MEIS1, MAP2K5/LBXCOR1, and BTBD9, for which genome-wide association studies in restless legs syndrome and periodic limb movements during sleep revealed common risk variants. DESIGN Case-control association study. SETTING Movement disorder clinic in Montreal. Subjects We typed 14 single-nucl...

BACKGROUND Prior studies have suggested unique patterns of neural activity associated with compulsive hoarding. However, to date no studies have examined the process of making actual decisions about whether to keep or discard possessions in patients with hoarding symptoms. An increasing body of clinical data and experimental psychopathology research suggests that hoarding is associated with imp...

objective: in spite of introduction of novel drugs, obsessive-compulsive disorder (ocd) has still found no suitable treatment. on the other hand, high rates of co-morbidity of ocd with bipolar spectrum disorders are increasingly recognized. mood switching and development of rapid cycling with antidepressants are significant problems in these patients. from this viewpoint, introducing a non-anti...

vitamin b6 is a cofactor of various enzymes influencing numerous neurotransmitters in the brain such as norepinephrin, and serotonin . since these neurotransmitters influence mood , the aim the present work to evaluate the effect of vitamin b6 on depression and obsessive compulsive behavior when coadministred with clomipramine, fluoxetine, or venlafaxine. male mice weighing 25-30 g were used. t...

Background: The purpose of this paper was to explore the impact of brand variables such as brand awareness, brand loyalty, brand attachment, and perceived brand quality on compulsive buying behavior. Methods: A self-administered questionnaire, containing demographic items and items related to compulsive buying, brand awareness, brand loyalty, brand attachment and perceived quality, was used to ...

The present case report describes an intensive treatment approach combining aggressive pharmacotherapy with daily cognitive behavioral therapy (CBT) directed at helping “Dee,” a 63-year-old female suffering from compulsive hoarding. The successful intervention consisted of individualized exposure and response prevention (ERP), in addition to cognitive restructuring to improve insight, decrease ...

Obsessive-compulsive disorder is characterized by the presence of recurrent and persistent thoughts, urges or images as well as repetitive behaviors or mental acts. According to the existing evidence, it can be predicted that difficulties in emotion regulation, impulsivity and anger are related to obsessive-compulsive disorder in one way or another. The aim of the present study was to predict o...