نتایج جستجو برای: comsia

تعداد نتایج: 217  

Journal: :Journal of molecular modeling 2012
Indrani Mitra Achintya Saha Kunal Roy

Antioxidants are important defenders of the human body against nocive free radicals, which are the causative agents of most life-threatening diseases. The immense biomedicinal utility of antioxidants necessitates the development and design of new synthetic antioxidant molecules. The present report deals with the modeling of a series of chromone derivatives, which was done to provide detailed in...

Journal: :Journal of chemical information and computer sciences 2004
Zhigang Zhou Jeffry D. Madura

HIV-1 RT is one of the key enzymes in the duplication of HIV-1. Inhibitors of HIV-1 RT are classified as nonnucleoside RT inhibitors (NNRTIs) and nucleoside analogues. NNRTIs bind in a region not associated with the active site of the enzyme. Within the NNRTI category, there is a set of inhibitors commonly referred to as TIBO inhibitors. Fifty TIBO inhibitors were used in the work to build 3-D ...

Journal: :SAR and QSAR in environmental research 2015
J Andrades J Campanini D Vásquez C Silvestri C Morales J Romero J Mella

A major problem today is bacterial resistance to antibiotics and the small number of new therapeutic agents approved in recent years. The development of new antibiotics capable of acting on new targets is urgently required. The filamenting temperature-sensitive Z (FtsZ) bacterial protein is a key biomolecule for bacterial division and survival. This makes FtsZ an attractive new pharmacological ...

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