Cells sense external concentrations and, via biochemical signaling, respond by regulating the expression of target proteins. Both in signaling networks and gene regulation there are two main mechanisms by which the concentration can be encoded internally: amplitude modulation (AM), where the absolute concentration of an internal signaling molecule encodes the stimulus, and frequency modulation ...

lead forms the complexes with xylenol orange in the basic solution. an adsorptivedifferential pulse stripping method for the determination of lead is proposed. the procedureinvolves an adsorptive accumulation of lead on a hanging mercury drop electrode (hmde) inthe presence of xylenol orange, followed by reduction of adsorbed lead by voltammetric scanusing differential pulse modulation. the opt...

toxocara canis (nematoda: ascaridae) is an intestinal nematode parasite of dogs, which can also cause disease in humans. transmission to humans usually occurs because of direct contact with t. canis eggs present in soil contaminated with the feces of infected dogs. this nematode has extraordinary abilities to survive for many years in different tissues of vertebrates, and develop to maturity in...

A new design of an immunosensor for viral molecules based on the ISFET nanoscale structure has been proposed. Physical processes take place inimmunosensor are modeled. The effect modulation surface potential interface between a semiconductor depleted layer (channel) and dielectric during interaction immobilization was used. Analytical expression source-drain current as function virus types conc...

Cardiac contraction is initiated by Ca(2+) leaving the sarcoplasmic reticulum through the ryanodine receptor (RyR). Although opening of the RyR can be modified by various ligands, these have no maintained effect on contraction. We conclude that modulation of the RyR controls sarcoplasmic reticulum Ca(2+) content rather than cytoplasmic Ca(2+) concentration.

The use of a near-infrared (NIR) laser for reversible modulation of a bubble-driven Janus polymer capsule motor is demonstrated. This process was mediated through illumination of the metal face of the Janus capsule motor at the critical concentration of peroxide fuel. Such an effective control of the propulsion of chemically powered microengines holds a considerable promise for diverse applicat...

Erythromycin, a reversal agent in multidrug-resistant cancer, was assayed in chloroquine resistance modulation. The in vitro microtechnique for drug susceptibility was employed using two freshly isolates of Plasmodium falciparum from North of Brazil. The antimalarial effect of the drug was confirmed, with an IC50 estimates near the usual antimicrobial therapy concentration, and a significant st...

We develop and analyze a best basis algorithm for orthonormal bases of local cosines which satisfy a uniform bound on their time-frequency concentration. All waveforms are obtained from three elementary window functions by shifts, rescaling, and modulation. For a discrete signal of length N, the complexity is of order N(logN) 2 .