The aim of the procedure is to determine the optimal sampling times for the assessment of AUC after administration of a drug, either as a single dose or during a regular dosing schedule. For a single dose, AUC is defined as the total area under the plasma concentration time profile from time zero to infinity; for a regular dosing interval at steady state, AUC is defined as the area under the pl...

Morphogen gradients are concentration fields of molecules acting as spatial regulators of cell differentiation in developing tissues and play a fundamental role in various aspects of embryonic development. We discovered a family of self-similar solutions in a canonical class of nonlinear reaction-diffusion models describing the formation of morphogen gradients. These solutions are realized in t...