Elderly patients frequently have concomitant diseases, triggering Background: the necessity of utilizing several different medications, which can cause adverse events associated with therapy, called polypharmacy. This study aimed to evaluate the main concomitant diseases with Alzheimer's disease (AD) and discuss possible interactions between drugs utilized to treat dementia and its comorbiditie...

Nerve block is the mainstay of therapy at pain clinics in Japan. The results of nerve blocks, namely the blocking of sensory pain pathways, vicious cycles of pain, sympathetic neural functions, and motor nerves are very useful in treating pain. If the same effects are to be obtained by drug administration, the concomitant use of many drugs with different actions is necessary, but even so, the e...

Over the last 10 years, trilostane, a competitive inhibitor of steroid synthesis, is being widely used for the treatment of canine hyperadrenocorticism. Trilostane causes a significant but reversible decrease in cortisol production and a concomitant improvement in clinical signs in most dogs with this common condition. Side effects, though infrequent, can be serious: dogs treated with this drug...

the marked shift in the patterns of drug use in iran, from opium smoking to injecting drug use, has led to serious health-related outcomes. this study was designed to explore characteristics of people who inject drugs (pwid) in tehran, iran. nine hundred and four pwid were recruited from treatment and harm reduction facilities, as well as drug user hangouts in public areas in tehran. participan...

In order to investigate the effect of pharmacist intervention on vancomycin use, this study was performed on all patients receiving vancomycin in the intensive care unit (ICU) and hematology-oncology ward of Taleghani Educational Hospital in Tehran, Iran. Vancomycin use was assessed during a pre- and post-intervention period in accordance with the Center of Disease Control and prevention (CDC) ...

BACKGROUND Prescription opioid use is highly associated with risk of opioid-related death, with 1 of every 550 chronic opioid users dying within approximately 2.5 years of their first opioid prescription. Although gabapentin is widely perceived as safe, drug-induced respiratory depression has been described when gabapentin is used alone or in combination with other medications. Because gabapent...

Increasing use of therapeutic proteins (TPs) in polypharmacy settings calls for more in-depth understanding of the biological interactions that can lead to increased toxicity or loss of pharmacological effect. Factors such as patient population, medications that are likely to be coadministered in that population, clearance mechanisms of a TP, and concomitant drugs have to be taken into account ...