BACKGROUND Clinically affected cystic fibrosis (CF) patients present a spectrum of genital phenotypes ranging from normal fertility to moderately impaired spermatogenesis and congenital bilateral absence of vas deferens (CBAVD). Little is known about the CF incidence in the Taiwanese population. It has been shown that the CBAVD in men without clinical evidence of CF is associated with a high in...

Inactivation of dynorphin-(1-8) in three in vitro isolated preparations, guinea-pig ileum, mouse vas deferens and rabbit vas deferens, was estimated by employing the relatively specific inhibitors of enkephalin-hydrolyzing enzymes. All three enzyme inhibitors, amastatin, captopril and phosphoramidon, significantly enhanced the inhibitory potency of dynorphin-(1-8) in the three isolated preparat...

Although men who have CF can enjoy a normal sex life, they are almost always (in about 98% of cases) infertile due to failure of the vas deferens, the tube which carries sperm from the testis to the penis, to develop properly (Kaplan et al, 1968). The epididymis sits on top of the testis like a cap. Normally the vas deferens carries the newly made sperm to the back of the prostate gland where i...

BACKGROUND Relaxin is the endogenous ligand of the G-protein coupled receptor RXFP1, previously known as LGR7. In humans relaxin can also activate, but with lower affinity, the closely related receptor for the insulin-like peptide from Leydig cells, RXFP2, previously known as LGR8. The lack of relaxin impairs male fertility but the precise distribution and the function of relaxin receptors in t...

The mule is a sterile hybrid domestic animal that results from the breeding of male donkey with female horse, understanding reproductive biology these species very critical. goal this paper was to perform comparative and more accurate histomorphometric testicles in Barb donkeys mules. Microscopic examinations histological description were carried on genital tract horses, mules healthy mature; s...

background: the genetic association between cystic fibrosis transmembrane conductance regulator (cftr) gene mutations and male infertility due to congenital bilateral absence of vas deferens (cbavd) is well established. mutant cftr, however may also be involved in the etiology of male infertility in non-cbavd cases. the present study was conducted to estimate the frequency of δi507 and δf508 cf...

Today, approximately 15% of couples have reduced fertility. In most cases the reason is male infertility, usually of genetic origin. Thus, in the context of research in genes involved in reproduction and sex determination, genetic defects in gametogenesis are being extensively studied. The most frequent pathogenic causes of male infertility are Y chromosomal microdeletions and obstructive azoos...

Congenital bilateral absence of the vas deferens (CBAVD) is found in 1-2% of infertile males and in most male cystic fibrosis (CF) patients. CF and some of the CBAVD cases were found to share the same genetic background. In this study, 21 males with CBAVD had extensive physical and laboratory testing for symptoms of CF. Possible defective cellular chloride transport was measured by interstitial...