Objective(s): MicroRNAs (miRNAs) are a subfamily of small noncoding RNAs that play a variety of roles in regulating gene expression in nearly all organisms. They affect different biological pathways by post-transcriptionally regulating mRNAs. Aside from miRNAs’  role in maintaining cellular homeostasis, their perturbation is related to several pathologic states and dis...

background: we sought to determine the frequency of the risk factors for congestive cardiac failure (ccf) in a tertiary care hospital in peshawar, pakistan. methods: this retrospective, observational study was conducted in the department of cardiology, postgraduate medical institute, lady reading hospital peshawar, from march 2005 to september 2007. relevant information regarding the risk facto...

AIMS Pulmonary hypertension (PH) in asymptomatic patients is a rare cause of sudden death. This study aims to determine the incidence of this entity and raise awareness among pathologists. METHODS We retrospectively investigated 44 cases of sudden unexpected death in relation to PH in patients not on antihypertensive therapy. This is the largest pathological study reported. RESULTS We repor...

A total of 14 cases of infective endocarditis (IE) in children aged 6 months to 10 years were seen from December 1987 to December 1992 at the pediatric unit of Ayatollah Taleghani Medical Center. The majority of patients (12 of 14) were between 5 and 10 years of age. Acyanotic congenital heart disease was known to preexist in 78.6% and rheumatic valvular heart disease in 21.4% of cases. Or...

BACKGROUND Ventricular tachycardia (VT) is an important cause of late morbidity and mortality in repaired congenital heart disease. The substrate often includes anatomic isthmuses that can be transected by radiofrequency catheter ablation similar to isthmus block for atrial flutter. This study evaluates the long-term efficacy of isthmus block for treatment of re-entry VT in adults with repaired...

This December Issue of Cardiology in the Young represents the 12th annual publication generated from the two meetings that compose "HeartWeek in Florida". "HeartWeek in Florida", the joint collaborative project sponsored by the Cardiac Center at the Children's Hospital of Philadelphia, Pennsylvania, together with Johns Hopkins All Children's Heart Institute of Saint Petersburg, Florida, average...

Introduction: Cornelia de Lange syndrome (CdLS) is a rare non-hereditary syndrome. The key diagnosis unique facial features, limb anomalies, and growth retardation. Cardiac defects with gastrointestinal genitourinary anomalies may be associated. Case Presentation: This case of neonatal CdLS that we think interesting due to its association novel congenital heart complex. Conclusions: Patients ha...

background: dextrocardia is a congenital anomaly, which may have coexistent coronary artery disease (cad), arrhythmias and conventional indications for device therapy. however, the implantation of transvenous leads can be technically challenging and the approach needs to be tailored to the patient's individual anatomy. case presentation: a 54-year-old male with dextrocardia situs inversus ...