A congenital neoplasm arising in the central nervous system is rarely encountered, and the majority of case reports that have dealt with intracranial tumors have been divided almost equally between teratomas and various gliomas. We experienced a rare case of congenital glioblastoma multiforme encountered in a three day-old male infant who presented with hydrocephalus since birth. Post-mortem ex...

The following is Dr. Shuttleworth's classification of mental defect (congenital) as follows:? Microcephalus, hydrocephalus, mongol or " Kalmuc " type, scrofulous cases, birth palsies with athetosis, congenital cretinism, and primary neurotic. The developmental types are eclamptic, epileptic, syphilitic (inherited), and the accidental or acquired are traumatic, postfebrile (both inflammatory), e...

Since the original description of a sex-linked mode of inheritance in congenital hydrocephalus (Bickers and Adams, 1949), subsequent reports have been published presenting additional families in which this inheritance pattern appeared to be present. Bamatter (1949) described a family in which the mother had delivered 2 hydrocephalic males and 3 normal females. Zimmer (1952) reviewed a family wi...

This report describes our first experience with a clinically important true false positive neonatal screening test for Duchenne muscular dystrophy (DMD). Neonatal screening for DMD began as a pilot programme in Manitoba on 1 January 1986 by analysis of creatine kinase (CK) activity in dried filter paper blood spots. To date, all except two males with positive initial and follow up neonatal CK s...

Background: Hydrocephalus is one of the most common clinical conditions affecting central nervous system and Ventriculoperitoneal (VP) shunt procedure used. We report an outcome analysis various risk factors etiological for failure in pediatric patients from a single institution. Methods: A institutional cross-sectional observational study was conducted 45 operated cases hydrocephalus below 16 ...

Normal pressure hydrocephalus (NPH) has posed a challenge to neurologists for 5 decades. Difficulties in understanding its pathophysiology have hindered efforts to diagnose it and to develop a better approach to selecting patients for shunt surgery. We know that many patients with NPH have CSF absorption difficulty as measured by resistance to CSF outflow (Rout). The problem is that many with n...

BACKGROUND To find out about the prenatal diagnosis rate of myelomeningocele (MMC) by ultrasound scan in patients referred to the Children's Hospital Medical Center in Tehran, Iran from July 2004 to July 2005. METHODS We included 140 children born with MMC and who were referred for management, surgery and treatment of complications associated with it. The ultrasound reports were examined. Dat...

Hydrocephalus is a common congenital anomaly. LCAM1 and MPDZ (MUPP1) are the only known human gene loci associated with non-syndromic hydrocephalus. To investigate functions of the tight junction-associated protein Mpdz, we generated mouse models. Global Mpdz gene deletion or conditional inactivation in Nestin-positive cells led to formation of supratentorial hydrocephalus in the early postnata...