tomy in infancy and the low expiratory flows which persist after lobectomy for congenital lobar emphysema, 15 subjects with this history were studied at age 8-30 yr. Total lung capacity was normal in all, but higher values (P < 0.05) were observed in nine subjects with upper lobectomy than in five subjects with right middle lobectomy. Ratio of residual volume to total lung capacity was correlat...

Although it has been conventionally believed that negative frequency dependence of respiratory resistance and deep decline of respiratory reactance during expiratory phase in COPD are due to ventilation inhomogeneity caused by small airway obstructions, there have been neither experimental theoretical evidence. We have recently confirmed that the airflow limitation site in COPD is the intra-med...

Interstitial emphysema (IE) is an uncommon lung disease associated with barotrauma, and is seen almost exclusively in neonates with respiratory distress syndrome. It is caused by the invasion of gas into the pulmonary interstitial space surrounding the bronchovascular bundles due to sudden changes in lung volumes and transpulmonary pressure. Secondary changes in the alveolar sacs cause the alve...