Background Duchenne Muscular Dystrophy (DMD) is a deadly X-linked recessive disorder. This genetic disorder affects 1 among 3,500-5,000 males in the world. The majority of the patients are male, due to the type of inheritance. It affects most of the skeletal, the respiratory, and cardiac muscles, causing these vital organs to contract and eventually mortality.<br...

In February, 2008, British environment minister Phil Woolas sparked a major row in the United Kingdom when he attributed the high rate of birth defects in the Pakistani community to the practice of marriages between first cousins. “If you have a child with your cousin, the likelihood is there’ll be a genetic problem,” he told the Sunday Times [1]. Although a Muslim activist group demanded that ...

BACKGROUND Peeling skin syndrome (PSS) is a rare genodermatoses of probable autosomal recessive inheritance. In Saudi Arabia, consanguinity of parents is common and consequently the occurrence of familial disease, including that of the skin, is not uncommon. METHODS To characterize the clinical and pathological features of PSS in Saudi Arabia, we reviewed the medical records and clinical phot...

OBJECTIVE To ascertain the incidence, and describe the various forms of neural tube defects (NTDs) due to genetic, chromosomal, and syndromic causes. METHODS We carried out a retrospective analysis of data retrieved from the medical records of newborn infants admitted to the Neonatal Intensive Care Unit with NTDs and their mothers spanning 14 years (1996-2009) at the Security Forces Hospital,...

Hereditary hemolytic disorders are important public health challenges in India. They cause a high degree of morbidity, mortality and fetal wastage in vulnerable communities. Tradition-bound-psychosocial influences are detrimental to the process of prevention. This study was designed to create awareness, motivate, and sensitize two major vulnerable tribal communities: Bhuyan and Kharia for hemog...

Purpose The practice of consanguinity has been culturally preferred in most Arab countries, including Morocco. This behavior leads to an increase genetic abnormalities, such as hypertension and diabetes. paper examines the prevalence determinants first-cousin marriages their impact on diabetes among offspring. Design/methodology/approach Data 882 couples were collected through face-to-face inte...

objective: although numerous studies have found higher rates of abortion and still births following consanguinity (familial marriages), the question of whether consanguinity significantly increases the risk of neonatal death has inadequately been addressed.this study aims to evaluate familial marriage effects on neonatal death in rural areas in iran. materials and methods: i n this nested case-...

japan, known as a pro-choice country in terms of abortion, is currently facing the increase of “selective abortions” thanks to new prenatal screening. efforts to restrict proliferation of new technology has not been successful and it is likely that japan will turn pro-life by strictly enforcing the maternity protection act (mpa), which prohibits abortions due to “fetal cause”.

mental retardation (mr) is one of the most frequently found major genetic disorders around the world, affecting 1-3% of the people in the general population. the recent advancement in molecular biology and cytogenetic study has made possible the identification of new genes for a variety of genetic disorders including autosomal recessive mr. recessive genetic disorders are common in pakistan due...