The present study was aimed to develop antihypertensive sustained release matrix tables of valsartan Angiotensin II receptor antagonist, using hydroxypropylmethylcellulose alone and in combination with ethyl cellulose as the matrix material in different proportion by wet granulation method. The granules were evaluated for angle o f repose, bulk density and Compressibility index. The tablets wer...

  Purpose: Patients may control postoperative pain by self-administration of intravenous opioids   using devices designed for this purpose (patient controlled analgesia or PCA). This study set out   to determine whether any of the two opioid administrations (i.e. PCA or conventional analgesia)   would provide superior pain relief among patients undergoing laparoscopic cholecystectomy   or not. ...

  Purpose: Patients may control postoperative pain by self-administration of intravenous opioids   using devices designed for this purpose (patient controlled analgesia or PCA). This study set out   to determine whether any of the two opioid administrations (i.e. PCA or conventional analgesia)   would provide superior pain relief among patients undergoing laparoscopic cholecystectomy   or not. ...

Pediatric patients are different from adult patients with respect to airway anatomy and breathing patterns. They are also incapable of following commands and often reject breathing treatments. For these reasons, aerosol drug delivery is one of the most technically challenging aspects for clinicians providing respiratory care to young children. Improvements in nebulizer technology have provided ...

Conventional parenteral injection of vaccines is limited in its ability to induce locally-produced immune responses in the respiratory tract, and has logistical disadvantages in widespread vaccine administration. Recent studies suggest that intranasal delivery or vaccination in the respiratory tract with recombinant viral vectors can enhance immunogenicity and protection against respiratory dis...

DNA vaccines are a promising method of immunization against biothreats and emerging infections because they are relatively easy to design, manufacture, store and distribute. However, immunization with DNA vaccines using conventional delivery methods often fails to induce consistent, robust immune responses, especially in species larger than the mouse. Intramuscular (i.m.) delivery of a plasmid ...

PURPOSE In this work a general method is presented that enables clinicians to rapidly select Rotating shield brachytherapy (RSBT) emission angles based on the patient-specific tradeoff between delivery time and tumor dose conformity. Cervical cancer cases are used as examples. METHODS Anchor plans with high dose conformity but infeasible delivery times are generated with a fine emission angle...

Recent advances in cancer genomics have opened up unlimited potential for treating cancer by directly targeting culprit genes. However, novel delivery methods are needed in order for this potential to be translated into clinically viable treatments for patients. Magnetic nanoparticle technology offers the potential to achieve selective and efficient delivery of therapeutic genes by using extern...