PURPOSE To assess the efficacy of an adjustable inspiratory occlusion valve in experimental bronchopleural fistula during mechanical ventilation. METHODS We studied six mechanically ventilated pigs in a surgically created, reproducible model of bronchopleural fistula managed with mechanical ventilation and water-sealed thoracic drainage. An adjustable inspiratory occlusion valve was placed be...

The aim of this study was to evaluate the effects of inhaled nitric oxide (iNO) therapy on oxygenation and mortality in children with acute respiratory distress syndrome (ARDS). Thirty-three children with ARDS and an arterial SatO2 <88% despite mechanical ventilation were analyzed. Patients in the iNO group were prospectively enrolled and treated with conventional therapy plus iNO. The control...

A 10-year-old, 36-kg child with a malignant air leak who failed conventional mechanical ventilation and high-frequency jet ventilation was successfully treated with a neonatal high-frequency oscillatory ventilator for 31 days. Since the air leak resolved with minimal hemodynamic compromise, this technique may have application in the management of respiratory failure and air leak in the older an...

BACKGROUND Dynamic intraesophageal pressure (Pes) is used to estimate intrapleural pressure (Ppl) to calculate lung compliance and resistance. This study investigated the nonhuman primate Ppl-Pes tissue barrier frequency response and the dynamic response requirements of Pes manometers. METHODS In healthy monkeys and monkeys with acute lung injury undergoing ventilation, simultaneous Ppl and P...

STUDY OBJECTIVE To determine whether the use of continuous i.v. sedation is associated with prolongation of the duration of mechanical ventilation. DESIGN Prospective observational cohort study. SETTING The medical ICU of Barnes-Jewish Hospital, a university-affiliated urban teaching hospital. PATIENTS Two hundred forty-two consecutive ICU patients requiring mechanical ventilation. INTE...

It is more than 15 years since high frequency oscillatory ventilation (HFOV) was first described as a technique of ventilation [ 1 ]. In the intervening period it has passed through a phase of being a physiological curiosity, where it could be demonstrated that normal gas exchange could be maintained using tidal volumes much smaller than deadspace at rates much greater than what was then consid...

vitamin e is a potent reactive oxygen metabolites (rom) scavenger. it is a lipid-soluble vitamin and its main function is to protect polyunsaturated fatty acids against oxidative stress. twenty-five mechanically ventilated intensive care unit (icu) adult patients participated in a prospective randomized clinical trial receiving either placebo (10 patients) or 3 im doses (1000 iu each) of vitami...

T lecture offers an approach in which the ventilator is used as a probe of the patient’s respiratory system mechanical derangements, and then the ventilator settings are tailored to the patient’s mechanical and gas exchange abnormalities. This facilitates early stabilization of the patient on the ventilator in such a way as to optimize carbon dioxide removal and oxygen delivery within the limit...

a bstract             mechanical ventilation is one of the major supportive interventions in intensive care units. weaning the patients from mechanical ventilation and its related criteria are of great importance due to the related complications. as there is no comprehensive standard to allocate the time of weaning and due to lack of local research in this fi eld, development of a comprehensive...