The structure of iso-grayanotoxin II, a new diterpenoid from Leucothoe grayana MAX., has been determined as 3 beta,5 beta,6 beta,14 beta,16 alpha-pentahydroxygrayanotox-9(10)-ene by spectroscopic and X-ray crystallographic analysis. The lethal dosage level of iso-grayanotoxin II in mice was lower than that of grayanotoxin III.

Recent research on vaccination has extended its scope from infectious diseases to chronic diseases, including Alzheimer disease, dyslipidemia, and hypertension. The aim of this study was to design DNA vaccines for high blood pressure and eventually develop human vaccine therapy to treat hypertension. Plasmid vector encoding hepatitis B core-angiotensin II (Ang II) fusion protein was injected in...

Based on a multimedia application framework a visual programming environment was built, that allows non-programmers to compose objects offered in the core framework without having to learn a programming language. Although having similarities with Opcode/IRCAM Max, our visual programming environment has some significant differences: Its connections are bi-directional, other media than MIDI, such...

Exercise hyperemia is attenuated in the elderly, which may be attributed to local vasoregulatory pathways within the skeletal muscle vasculature. Therefore, we sought to determine whether healthy aging is associated with changes in angiotensin II (Ang II) receptor sensitivity through measurements of leg blood flow in resting and exercising skeletal muscle. In 12 (n=6 young, 24+/-1 years; n=6 ol...

We discuss the electromagnetic collisions of high energy protons, pions and kaons with atmospheric nuclei. In particular, we use equivalent photon approximation to estimate (i) diffractive where projectile scatters inelastically off a nucleus, (ii) usual radiative processes (bremsstrahlung, pair production photonuclear interactions) these charged hadrons in air. then include simulator AIRES stu...

To investigate the venoconstrictor effect of angiotensin II (Ang II) in spontaneously hypertensive rats (SHR), we used preparations of mesenteric venular beds and the circular muscle of the portal veins. Vessels were tested with Ang II in the presence or absence of losartan, PD 123319, HOE 140, L-NAME, indomethacin, or celecoxib. In the mesenteric venular bed of SHR, the effect of Ang II (0.1 n...

Two simple UV-Spectrophotometric methods have been developed for simultaneous determination of Rosuvastatin calcium and Fenofibrate in pharmaceutical formulation. Methanol AR grade was used as solvent. In Method-I (Qabsorbance absorbance ratio) involves formation of Q-absorbance equation at two wavelengths i.e. 255.99 nm (isoabsorptive point) and 286 nm (λ max of Fenofibrate). While, in Method-...