Here we report the first experimental detection of the Cs symmetric nitroformyl radical, OCNO(X A00) in a nitrogen–carbon dioxide matrix at 10 K using a Fourier transform infrared spectrometer (FTIR). The n1 vibrational frequency was observed at 2113 cm . This assignment was confirmed by follow-up experiments using isotopically labeled reactant molecules (N, O, C). To synthesize this radical, w...

In a preliminary communication last year' we stated that there are only two helical configurations of polypeptide chains in which the residues are all equivalent and intramolecular hydrogen bonds are formed, and in which the interatomic distances, bond angles, and other structural features, especially the coplanarity of the conjugated amide system, are as required by earlier work in these Labor...

Chemists, like artists, are able to construct new threedimensional objects, molecules and materials that exist only in the mind of a person. I became interested in creating novel molecular shapes with properties different from those found in nature shortly after arriving at Caltech in 1973. One cannot design without the brushes and paint of the craft. Indeed, modern organic chemists, standing o...

Within the realm of medicinal chemistry, synthesis plays a pivotal role in any drug research and development endeavor. The ability to design elegant and economical synthetic routes is often a major factor for making a drug a commercial winner. Retrosynthetic analysis/ Synthon disconnection approach, introduced and advanced by Prof. E. J. Corey of Harvard University has served as a powerful driv...

Saucedo, Corey K. Goldman, John Blebea, Jennifer Macko, Paul D. Kessler, Henrik S. Sanjay Rajagopalan, Emile R. Mohler III, Robert J. Lederman, Farrell O. Mendelsohn, Jorge F. Claudication of Vascular Endothelial Growth Factor 121 in Patients With Disabling Intermittent Disease : A Phase II Randomized, Double-Blind, Controlled Study of Adenoviral Delivery Regional Angiogenesis With Vascular End...

Addition of lithiated alkyl dithianes to benzoyl chloride or methyl benzoate does not produce the expected product of double addition, alpha,alpha-bis(alkyldithianyl) benzyl alcohol, for alkyls larger than methyl. Instead, the first step intermediate, i.e. 2-benzoylated dithiane, undergoes an electron-transfer reduction by the second molecule of the dithianyl anion. This reduction is followed b...

Frederick W. Alt Don L. Anderson Michael Ashburner Stephen J. Benkovic David E. Bloom Floyd E. Bloom Piet Borst Henry R. Bourne Michael S. Brown James J. Bull Kathryn Calame C. Thomas Caskey Dennis W. Choi John M. Coffin Paul J. Crutzen James E. Dahlberg Robert Desimone Bruce F. Eldridge Paul T. Englund Richard G. Fairbanks Douglas T. Fearon Harry A. Fozzard Klaus Friedrich Theodore H. Geballe ...

In this paper we consider the process of one-dimensional redistribution of two immiscible and incompressible uids in a heterogeneous porous medium. We treat in detail the special case in which the initial saturation as well as the properties of the porous medium have a single coinciding discontinuity. Then the time-dependent saturation proole is of self-similar form, i.e. depends only on x= p t...

William T. Golden Treasurer Richard S. Nicholson Executive Officer John Abelson Frederick Alt Don L. Anderson Stephen J. Benkovic Gunter K-J Blobel Floyd E. Bloom Henry R. Boume James J. Bull Kathryn Calame Charles R. Cantor Ralph J. Cicerone John M. Coffin Robert Dorfman Bruce F. Eldridge Paul T. Englund Federic S. Fay Harry A. Fozzard Theodore H. Gaballe Roger 1. M. Glass Stephen J. Goff Core...

Which Biomarkers Reveal Neonatal Sepsis? Supplementary Material Kun Wang, Vineet Bhandari, Sofya Chepustanova, Greg Huber, Stephen O’Hara, Corey S. O’Hern, Mark D. Shattuck, Michael Kirby 1 Department of Mathematics, Colorado State University, Fort Collins, CO, USA 2 Department of Mechanical Engineering & Materials Science, Yale University, New Haven, CT, USA 3 Division of Perinatal Medicine, D...