INTRODUCTION AND PURPOSE Various conditions may cause vascularization of the normally avascular cornea. The aim of the present study was to create a reproducible experimental model that could enable the investigation of the phenomena leading to corneal vascularization. This involved creating a software to record the experimental data, enabling a subsequent digital analysis based on the growth m...

We will present the latest information about cataract surgery-induced corneal endothelial damage, explain the best practices and discuss how damage can be minimized. We will also present our work on two other causes or corneal problems: wound burn and toxic anterior segment syndrome. Emphasis will be on understanding the pathophysiology and how to best avoid these uncommon but potentially devas...

PURPOSE The present study was conducted to investigate healing of alkali-burned corneas in MRL/MpJ (MRL) mice. METHODS Gross, clinical, and histologic criteria were used to compare healing of alkali-burned corneas in MRL and control C57BL/6J (B6) mice. Effects of neutrophil depletion of B6 mice and allogeneic reconstitution of B6 mice with MRL bone marrow on wound healing were evaluated. Gene...

PURPOSE To evaluate the roles of ADP-ribosylation factor (ARF) in alkali-induced corneal neovascularization (CNV). METHODS CNV was induced by alkali injury and compared in ARF1 inhibitor- or vehicle-treated mice 3 weeks after injury. Angiogenic and apoptosis factor expression in corneas after injury was quantified with reverse-transcription PCR. Human retinal endothelial cell apoptosis induce...

Program Number: 13 Poster Board Number: A0001 Presentation Time: 8:30 AM–10:15 AM Immunohistochemical observation of meibomian gland following ocular surface alkali burning in wild-type and Smad3-deficient mice Shin Mizoguchi1, Yuka Okada1, Reiko Arita2, Shizuya Saika1. 1Ophthalmology, Wakayama Medical University, Wakayama, Japan; 2Ophthalmology, Itoh Clinic, Saitama, Japan. Purpose: To immunoh...

The purpose of this study is to characterize and compare the ultrastructural changes occurring during the in vivo cultivation of corneal epithelium on amniotic membrane (AM) at several different time points. Corneal burn patients (n=7) with a corneal epithelial defect and severe limbal damage were selected. Initially, AM transplantation with limbal autograft was performed at the acute stage of ...

INTRODUCTION Contractures, ectropion and scarring, the most common sequelae of skin grafts after eyelid burn injuries, can result in corneal exposure, corneal ulceration and even blindness. Split-thickness or full-thickness skin grafts are commonly used for the treatment of acute eyelid burns. Plasma exudation and infection are common early complications of eyelid burns, which decrease the succ...

background: the incidence of caustic ingestion injuries in developed countries has been decreasing, while it still remains a great concern in developing countries including iran. in this study we focused on alkali esophageal injuries in children which occur frequently in southern iran, due to both, unsafe products and unfamiliarity of families with the alkali consumption hazards. methods : in a...

Objective to compare the inflammatory response between platelet rich plasma 20% and autologous serum on cornea after sodium hydroxide exposure. Methods a true experimental study with two groups post-test design. A total of 18 rabbits were used in this allocated into groups. After collecting intravenous blood samples from both group, 20%, respectively, obtained by centrifugation dilution. Alkali...