BACKGROUND Corneal ulcer is an important cause of blindness in developing countries. Therapeutic keratoplasty for infective keratitis is a frequently performed surgery in these countries. OBJECTIVE To find out the outcome of therapeutic keratoplasty for infective keratitis. METHODS Records of 5 years were reviewed of patients who underwent therapeutic keratoplasty from 2006 to 2010. Data co...

purpose : the aim of this study was to determine indications of keratoplasty during 7 years (1999–2006) in emam-rreza and vali-asr teaching hospitals of birjand university of medical sciences. methods : medical records of all patients who underwent penetrating keratoplasty (pk) in teaching hospitals of birjand university of medical sciences from 1999 to 2006 were investigated retrospectively. t...

purpose : to report a case of recurrent corneal intrastromal cyst containing lymph fluid case report : a 13-year-old girl presented with recurrent cyst of the left cornea, which had been drained three years before, but had gradually recurred. the cyst was successfully drained. histologic examination, cytologic analysis, and protein electrophoresis were performed on the cyst fluid. histopatholog...

Corneal endothelial cells (CECs) are essential for maintaining the clarity of the cornea. Because CECs have limited proliferative ability, interest is growing in their potentially therapeutic regeneration from pluripotent stem cells. However, the molecular mechanisms of human CEC differentiation remain largely unknown. To determine the key regulators of CEC characteristics, here we generated a ...

Lumican is keratan sulfate proteoglycan of the small leucine rich proteoglycan family. Through studies in animal models lumican has been found to be critical in maintaining corneal clarity. It maintains ordered collagen fibrils which are vital in keeping the cornea transparent. It may also be important in primary open angle glaucoma influencing aqueous outflow. Lumican deficiency in mice result...

High endothelial cell density (ECD) is essential for the corneal graft clarity. We evaluated ECD loss in 120 eyes that underwent penetrating keratoplasty (PK) in Eye Clinic Svjetlost in a one year follow up period. Patients were divided into 3 groups of high (N = 35), intermediate (N = 31) and low risk (N = 54) for graft failure. Postoperative central endothelial density, coefficient of variati...

PURPOSE To evaluate the efficacy of a controlled release dexamethasone delivery system for suppressing inflammation in an ocular burn + desiccating stress (OB+DS) model. METHODS Nanowafers (NW) loaded with Dexamethasone (Dex, 10 μg) or vehicles (2.5% Methylcellulose; MC) were fabricated using hydrogel template strategy. C57BL/6 mice were subjected to unilateral alkali ocular burn with concomi...

Olivier Richoz, MD, has won the 24th Annual Richard C. Troutman, MD, DSc (Hon) Prize and $5000 award for an article published in the Journal of Refractive Surgery: “Antibacterial Efficacy of Accelerated Photoactivated Chromophore for Keratitis–Corneal Collagen Cross-linking (PACK-CXL)” by Olivier Richoz, Sabine Kling, Florence Hoogewoud, Arthur Hammer, David Tabibian, Patrice Francois, Jacques ...