microbial corneal diseases are a serious ocular infection and the major cause of ocular morbidity and blindness in the world. the outcomes of fungal keratitis are unfavorable due to the protracted course of the condition and the diversity of respective clinical presentations. trauma, contact lens wear, foreign material, and prior corneal surgery, may make the most background for permitting inva...

BACKGROUND Rabbits are currently not a good model for studying diseases of the corneal endothelium because their corneal endothelial cells (CECs) maintain a high proliferative capacity throughout almost all their life. Addressing this particular feature might allow the use of this species for such a purpose. The aim of this study was to evaluate the corneal endothelial injury after intracameral...

IL-17A is a proinflammatory cytokine that has received attention for its role in the pathogenesis of several autoimmune diseases. IL-17A has also been implicated in cardiac and renal allograft rejection. Accordingly, we hypothesized that depletion of IL-17A would enhance corneal allograft survival. Instead, our results demonstrate that blocking IL-17A in a mouse model of keratoplasty accelerate...

BACKGROUND/AIMS Stevens-Johnson syndrome (SJS), ocular cicatricial pemphigoid (OCP) and alkali burns are associated with chronic, severe inflammation of the ocular surface that occasionally lead to corneal stem cell deficiencies. The corneal stroma in these diseases has not been studied comprehensively. The purpose of this study was to determine whether the keratocytes in the stroma were normal...

PURPOSE Our aim was to assess the corneal power, axis, and age dependence of the anterior and posterior corneal surfaces with Scheimpflug imaging. METHODS Patients older than 10 years without a history of ocular surgery, corneal diseases, contact lens wearing, or severe dry eye were enrolled. Data regarding the anterior and posterior cornea were analyzed by means of Scheimpflug imaging (Penta...

Corneal transplantation is an important surgical treatment for many common corneal diseases. However, a worldwide shortage of tissue from suitable corneal donors has meant that many people are not able to receive sight-restoring operations. In addition, rejection is a major cause of corneal transplant failure. Bioengineering corneal tissue has recently gained widespread attention. In order to f...

Biologics, like peptides, proteins and nucleic acids, have proven to be promising drugs for the treatment of numerous diseases. However, besides off label use monoclonal antibody bevacizumab corneal neovascularization, date no other biologics diseases reached market. Indeed, delivering in eye remains a challenge, especially at level cornea. While it appears rather accessible tissue administrati...

Background: The effect of corticosteroid therapy on corneal wound healing is controversial. The objective of this study was to evaluate the effects of combination therapy with dexametha-sone and acetylcysteine at different times and durations on experimentally-induced corneal wounds and haze in rabbits. Methods: Eighteen adult New Zealand white rabbits were divided into three groups of ...

PURPOSE Ocular neovascularization is the primary cause of blindness in a wide range of prevalent ocular diseases including proliferative diabetic retinopathy, exudative age-related macular degeneration, and retinopathy of prematurity, among others. Antiangiogenic therapies are starting to give promising results in these diseases. In the present study the antiangiogenic potential of an 18-mer pe...

Introduction In recent years, reduced corneal biomechanics have been identified as an important element in the pathogenesis of various corneal diseases. The biomechanical characteristics of a connective tissue such as strength and resistance against mechanical stress are indispensable prerequisites to maintain regular shape and function of that tissue. Intraand intermolecular cross-links betwee...