A combined nonlinear optical microscopy (NLOM) and optical coherence microscopy (OCM) imaging system has been assembled in order to simultaneously capture co-registered volumetric images of corneal morphology and biochemistry. Tracking of cell nuclei visible in the OCM volume enabled the calculation of strain depth profile in response to changes in intraocular pressure for rabbit cornea stroma....

Excimer laser ablation has been proposed as a technique for keratorefractive surgery. Clinical acceptance of linear-incision laser keratectomy may depend on the availability of a method for accurately and noninvasively monitoring incision depth during the ablation process. We have developed a femto-second optical ranging technique for measurement of corneal incision depth. This technique uses n...

In this work, optical retardation (OR) was investigated in corneal stroma collagen fibers from nonobese diabetic (NOD) and healthy (BALB/c) mice. Linear dichroism (LD) was investigated in corneas stained with Ponceau SS and Toluidine Blue, using microspectrophotometer. NOD corneas showed higher OR values than the control. Ponceau SS-complexed collagen fibers showed positive LD that was higher f...

In this paper, we present a high accuracy laser range finder and velocimeter using ultra-fast time-to-digital converter (TDC). The system operation is based on the measuring the round-trip time of a narrow laser pulse. A low-dark current high-speed PIN photodiode is used to detect the triggered laser beam and to produce start signal. The pulsed laser diode generates 45W optical power at 30ns du...

Purpose The human eye has typically more optical aberrations than conventional artificial optical systems. While the lower order modes (defocus and astigmatism) are well studied, our purpose is to explore the influence of genes versus the environment on the higher order aberrations of the optical components of the eye. Methods We have performed a classical twin study in a sample from the Regi...

Corneal grafts for Descemet's Stripping Automated Endothelial Keratoplasty are commonly prepared using mechanical microkeratomes. However, the cuts produced in such way render corneal lenticules that are thinner centrally than peripherally, thus inducing a hyperopic shift. Here we describe a novel device for preparing donor corneal grafts, in which a single low-energy femtosecond laser system i...

Background: The optic nerve damage with the ultimate loss of vision resulting from a clutch diseases named Glaucoma. In many conditions including, corneal dystrophies, edema, and endothelial cornea, important biometric is Central thickness (CCT). Objective: To find difference in mean CCT spectral-domain optical coherence tomography ultrasound pachymetry patients presenting Material & Method...

Corneal scarring remains a major cause of blindness world-wide, with limited treatment options, all of which have side-effects. Here, we tested the hypothesis that topical application of Rosiglitazone, a Thiazolidinedione and ligand of peroxisome proliferator activated receptor gamma (PPARγ), can effectively block scar formation in a cat model of corneal damage. Adult cats underwent bilateral e...

in order to implement an integrated optical quantum circuit, designing waveguides based on the quantum box is of prime importance. to do this we have investigated optical waveguide both with and without optical pumping. the rate of absorption and emission using an array of algaas/gaas quantum box core/shell structure in the optical waveguide with various pumping intensities has computed. by con...

PURPOSE To investigate the topography of the central and peripheral cornea in a group of young adult subjects with a range of normal refractive errors. METHODS Corneal topography data were acquired for 100 young adult subjects by a method that allows central and peripheral maps to be combined to produce one large, extended corneal topography map. This computer-based method involves matching t...