purpose : the aim of this study was to determine indications of keratoplasty during 7 years (1999–2006) in emam-rreza and vali-asr teaching hospitals of birjand university of medical sciences. methods : medical records of all patients who underwent penetrating keratoplasty (pk) in teaching hospitals of birjand university of medical sciences from 1999 to 2006 were investigated retrospectively. t...

The purpose of this study was to compare the topical anti-inflammatory effects of the nonselective cyclooxygenase (COX) inhibitor, ketorolac, with the selective COX-2 inhibitor, nimesulide, in an animal model of dry eye in albino rabbits. All animals were examined by the Schirmer test, tear break-up time (TBUT) and fluorescein corneal staining test. Dry eye model showed significant reduction in...

The pharmacokinetics of linezolid was assessed in 20 adult volunteers with body mass indices (BMI) of 30 to 54.9 kg/m(2) receiving 5 intravenous doses of 600 mg every 12 h. Pharmacokinetic analyses were conducted using compartmental and noncompartmental methods. The mean (±standard deviation) age, height, and weight were 42.2 ± 12.2 years, 64.8 ± 3.5 in, and 109.5 ± 18.2 kg (range, 78.2 to 143....

Results from a proposed equation for rebreathing systems, (formula: see text), were compared with results from a mechanical model "lung" ventilated either with a Bain Breathing Circuit, or a circle system (Eger-Ethans type A) without soda lime. When values for carbon dioxide excretion (VCO2), dead spacetidal volume ratio (VD/VT), minute volume ventilation (VE), and fresh gas flow (VF) were vari...

The pharmacokinetic profiles of atracurium and one of its derivatives, laudanosine were studied following an i.v. bolus of atracurium 0.6 mg kg-1 administered to eight patients with hepatic cirrhosis and to seven healthy controls. The central volume of distribution of atracurium was greater in the patients with cirrhosis (104.6 ml kg-1) compared with the controls (69.6 ml kg-1) (P less than 0.0...

BACKGROUND Reference tissue-based quantification of brain PET data does not typically include correction for signal originating from blood vessels, which is known to result in biased outcome measures. The bias extent depends on the amount of radioactivity in the blood vessels. In this study, we seek to revisit the well-established Logan plot and derive alternative formulations that provide esti...

Kinetic analysis of inert tracers shows that some of the most important parameters such as the average turnover rate and the total volume of distribution can be calculated only if the entire time course of the tracer clearance is known. This means that extrapolation beyond the observation period (to infinity) must necessarily be accomplished. This paper presents arguments to support the monoexp...

backgrounds: thyroid hormones play an important physiological role in human metabolism. erythrocyte abnormalities are frequently associated with thyroid disorder. however, they are rarely investigated and related to the subclinical and primary hypothyroidism in kashmiri patients. in this study an attempt was made to study hematological parameters in untreated and treated subclinical hypothyroid...

Acellular corneal stroma matrix has been used for corneal stroma engineering. However, because of its compact tissue structure, regrowth of keratocytes into the scaffold is difficult. Previously, we developed a sandwich model for cartilage engineering using acellular cartilage sheets. In the present study, we tested this model for corneal stroma regeneration using acellular porcine corneal stro...

PURPOSE Stratified squamous epithelial cells assemble a specialized protective barrier structure on their periphery, termed the cornified envelope. The purpose of this study was to evaluate the presence and distribution of cornified envelope precursors in human corneal epithelium, their expression in human corneal epithelial cell cultures, and the effect of ultraviolet radiation (UVB) and trans...