We investigated neuronal uptake of noradrenaline (NA) at the level of larger vessels (thoracic aorta and vena cava left renal artery and left renal vein lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal ear vein) in a model devised to mimic heart failure. The model presented here is the rabbit coronary ligation model in which myocardial infarcti...

A vectorcardiographic method has been developed for determining the absolute size of myocardial infarcts in baboons resulting from coronary artery ligation. Spatial area (mvolt . msec) and voltage (mvolt) difference-vectors were obtained for 8 animals by measuring the voltage loss and temporal deviation from pre- to post-ligation McFee scalar leads. The difference vectors were then correlated w...

To elucidate the mechanism of regional hemostasis in the left ventricular (LV) cavity during myocardial infarction, the blood pathway in LV cavity was examined with contrast echocardiography injected from the left atrium before and after coronary ligation in nine canines. Before coronary ligation, contrast echoes spread over LV cavity with one rush. After ligation, smokelike echoes indicating h...

AIMS Heart failure (HF) is a major cause of death and morbidity. Connexin 43 (Cx43) content is reduced in the failing myocardium, but regulating factors have not been identified. In HF, inducible nitric oxide synthase (iNOS)-induced high levels of nitric oxide (NO) cause apoptosis and cardiac dysfunction. However, a direct iNOS-Cx43 link has not been demonstrated. We investigated this relations...

The aim of the work is to study effect anxiolytic fabomotizole (15 mg/kg, i.v.) on atrial depolarization in acute phase myocardial infarction using method synchronous multichannel cardioelectrochronotopography. Synchronous cardioelectrochronotopography was used sequence epicardium outbred rats during caused by ligation anterior branch left coronary artery with simultaneous administration σ1-rec...

The effect of halothane on myocardial infarction caused by ligation of the left descending coronary artery was studied in rats. The extent of infarction was quantified 48 hours after ligation of the artery by planimetric measurement of left ventricular slices stained with nitrobluetetrazolium. Animals exposed to halothane one per cent for three hours after the coronary ligation were compared wi...

We used a canine preparation of experimental infarction to study the natural course of echocardiographically defined regional wall motion abnormalities in the 6 weeks after acute coronary ligation. Eight dogs underwent serial short-axis echocardiographic evaluation and microsphere blood flow determinations at control, and 30 min, 48 hr, 1 week, 3 weeks, and 6 weeks after acute coronary artery l...

Electrocardiograms and electrograms were recorded in 18 dogs anesthetized with sodium pentobarbital. Using endocardial and epicardial plunge wire electrodes in normal and ischemic or infarcted areas, activation of Purkinje and regular muscle tissue was studied within the first 20-30 minutes and 24 hours after anterior descending coronary artery ligation. The ventricular arrhythmias in the first...

background: coronary arteriovenous fistulas (cavfs) are direct connections from one or more coronary arteries to cardiac chambers or a large vessel. they are mostly of congenital origin. the aim of this study was to describe clinical presentation and also delineate the course and management of cavf. methods: clinical data, chest x-rays, echocardiographic and angiographic evaluation of 40 patien...

To elucidate the mechanism of regional hemostasis in the left ventricular (LV) cavity during myocardial infarction, the blood pathway in LV cavity was examined with contrast echocardiography injected from the left atrium before and after coronary ligation in nine canines. Before coronary ligation, contrast echoes spread over LV cavity with one rush. After ligation, smokelike echoes indicating h...