The arcuate fasciculus (AF) connects cortical regions important in language processing, but how fiber coherence and organization relates to gray matter macrostructure remains uncharacterized. We used high-resolution structural and 30-direction diffusion imaging data from 36 healthy adults (24 male/12 female; mean age, 30.5 ± 9.8 years) to establish the relationships between AF microstructure an...

BACKGROUND A structural neuroanatomical change indicating a reduction in brain tissue is a notable feature of schizophrenia. Several pathophysiological processes such as aberrant cortical maturation, progressive tissue loss and compensatory tissue increase could contribute to the structural changes seen in schizophrenia. METHOD We studied cortical thickness using surface-based morphometry in ...

In quantifying the amount of gray matter in a population, voxelbased morphometry (VBM) and cortical thickness analysis are the two most widely used techniques. There are still many unanswered methodological questions regarding these methods. It is not clear what is the optimal amount of registration needed in VBM. It is assumed that the gray matter density obtained in the VBM will be positively...

The cerebral cortex is a distinctive part of the mammalian nervous system, displaying a spatial variety in cyto-, chemico-, and myelinoarchitecture. As part of a rich history of histological findings, pioneering anatomists von Economo and Koskinas provided detailed mappings on the cellular structure of the human cortex, reporting on quantitative aspects of cytoarchitecture of cortical areas. Cu...

Studies have found abnormalities of resting EEG measures of hemispheric activity in depressive disorders. Similar EEG findings and a prominent thinning of the cortical mantle have been reported for persons at risk for depression. The correspondence between EEG alpha power and magnetic resonance imaging (MRI) measures of cortical thickness was examined in a multigenerational study of individuals...

Number: 1736 Submitted By: Yasser Ad-Dab'bagh Last Modified: 11 Jan 05 Native-Space Cortical Thickness Measurement And The Absence of Correlation to Cerebral Volume Yasser Ad-Dab'bagh1,2,5,6, Vivek Singh5,6, Steven Robbins3,5,6, Jason Lerch2,5,6, Oliver Lyttelton2,5,6, Eric Fombonne1,6, Alan Evans2,4,5,6 1Department of Psychiatry, 2Department of Neurology and Neurosurgery, 3School of Computer S...

BACKGROUND Schizophrenia is a disorder of brain connectivity and altered neurodevelopmental processes. Cross-sectional case-control studies in different age groups have suggested that deficits in cortical thickness in childhood-onset schizophrenia may normalize over time, suggesting a disorder-related difference in cortical growth trajectories. METHODS We acquired magnetic resonance imaging s...

OBJECTIVES We aimed to determine the precision of the Laplacian approach for cortical thickness measurement due to changes in computational and acquisition parameters. We compared these results to two other methods widely used in clinical research using brain MRI data. MATERIALS AND METHODS Brain MRI scans were obtained in 10 healthy adults using three different sets of acquisition parameters...

CONTEXT Whether cortical thickness changes in schizophrenia over time are more pronounced relative to the changes that can be attributed to normal aging has not been studied. OBJECTIVE To compare patients with schizophrenia and healthy control participants on cortical thickness change. DESIGN A 5-year longitudinal study comparing schizophrenic patients and healthy controls using 2 magnetic ...

BACKGROUND As longevity of cementless femoral components enters the third decade, concerns arise with long-term effects of fixation mode on femoral bone morphology. We examined the long-term consequences on femoral remodeling following total hip arthroplasty with a porous plasma-sprayed tapered titanium stem. METHODS Clinical data and radiographs were reviewed from a single center for 97 rand...