Bauer (1954), in reviewing 60 cases of hypothalamic syndrome reported at all ages in the literature, named the principal signs in descending order of frequency as precocious puberty, hypogonadism, diabetes insipidus, psychic disturbances, somnolence, obesity, thermodysregulation, emaciation, convulsions, sphincter loss, bulimia, anorexia and dyshydrosis. Some of the above signs are clearly due ...

The hypothalamus is one of the most studied areas of the central nervous system. Many of its functions are understood and there is an extensive literature on its role in the control of pituitary hormone secretion, autonomic nervous system activity, regulation of salt, water and food ingestion, body temperature regulation and aspects of behaviour. Although the role of the hypothalamus in the con...

BACKGROUND Increased cortisol levels and genetic polymorphisms have been related to both major depressive disorder and antidepressant treatment outcome. The aim of this study is to evaluate the relationship between circadian salivary cortisol levels, cortisol suppression by dexamethasone and genetic polymorphisms in some HPA axis-related genes to the response to placebo and fluoxetine in depres...