Administration of a moderately large or large dose of cortisone to dogs having acute myocardial infarctions inhibited slightly the rate of removal of necrotic muscle fibers in these animals as compared with untreated animals. Delay was appreciable at four and six days after production of the infarct in animals receiving 2.5 mg. of cortisone per kilogram of body weight and at 4, 6, 12 and 21 day...

A rabbit model in which intrinsic clotting was selectively impaired by injection of a human factor VIII antibody was used to evaluate the mechanism of endotoxininduced intravascular clotting in cortisonetreated rabbits. Three groups of animals were studied: a control group given factor VIII antibody followed by saline; a second control group given an inert material followed by endotoxin; and an...

acid and protein metabolism in the normal liver tissue. Following i.m. administration of hydrocortisone in mice, electron microscopic examination of the liver was performed from 1 to 48 hr after the injection and an increase in mitochondria in the sections of liver cells was demonstrated. Using morphometric and stereographic techniques combined with statistical analysis, a curve was constructed...

THE following is ajsummary of the literature on this subject. Wall and Shure (Los Angeles) 1952, treated five cases of polypi by subjnucous injection of the turbinates. The turbinates shrank up and made removal of the polypi easier. Sidi and Tardiff in Paris, 1955, injected the anterior third of the inferior turbinates and also the septum. W'alter Owen, 1956, injected Hydrocortisone into the su...

Harris and Harris ( 8) studied the influence of general treatment with cortisone and ACTH on the tuberculin reaction in guinea-pigs and rabpits. They found that these hormones inhibit the local and general reactions to tuberculin but do not prevent the Arthus phenomenon. As soon as the treatment was stopped, the hypersensitivity reappeared within 4 days. Derbes and collaborators (4) found that ...

Two elderly patients with mineralocorticoid excess state due to 11 β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) impairment are described. Moreover, the role of the precursor-product ratios of the steroids reflecting 11β-HSD2 activity was estimated in 5 patients, including 3 patients reported previously by us. Significant elevations of urinary cortisol/cortisone ratios were observed, whereas...

mon cell emboli. Some blood-borne emboli can no circulate (4—7,9—li). Probably such emboli are not sources of metastases unless they are arrested ultimately in sites favorable for their development (3). This report concerns the effect of cortisone on arrest of tumor cell emboli. Past investigations have shown that cortisone increases metastases (1, 2). Cortisone may promote metastases by in...

CORTISONE and hydrocortisone are now widely used in the treatment of ocular inflammations, particularly in allergic conditions such as phlyctenular keratoconjunctivitis, vernal conjunctivitis, scleritis, uveitis, and some kinds of keratitis. In the treatment of diseases in the anterior segment of the eye, an inexpensive topical application in the form of a suspension or ointment may be used wit...

Necrotizing enterocolitis is the most frequently occurring gastrointestinal disorder in premature neonates. Animal models of necrotizing enterocolitis and prenatal administration of cortisone have demonstrated that cortisone may accelerate maturation of the mucosal barrier, therefore reducing the incidence of this gastrointestinal disorder. The authors present a review of the literature of the ...

A rabbit model in which intrinsic clotting was selectively impaired by injection of a human factor VIII antibody was used to evaluate the mechanism of endotoxininduced intravascular clotting in cortisonetreated rabbits. Three groups of animals were studied: a control group given factor VIII antibody followed by saline; a second control group given an inert material followed by endotoxin; and an...