1 The Lancet. Solutions to the R&D crisis for neglected diseases. Lancet 2008; 372: 1784. 2 Bachmann C, Krähenbühl S, Colombo JP, Schubiger G, Jaggi KH, Tönz O. N-acetylglutamate synthetase defi ciency: a disorder of ammonia detoxication. N Engl J Med 1981; 304: 543. 3 Caldovic L, Morizono H, Panglao MG, et al. Cloning and expression of the human N-acetyglutamate synthase gene. Biochem Biophys ...

From the University Clinic, Department of Internal Medicine, Division VII: Sports Medicine, Heidelberg, Germany (P.B.); and Pulmonary and Critical Care Medicine, Department of Medicine, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle (E.R.S.). Address reprint requests to Dr. Bärtsch at the University Clinic, Department of Internal Medicine, Division VII: Sport...

BACKGROUND Although information about the incidence of viral respiratory illnesses and their associated cost can help health officials explore the value of interventions, data are limited from middle-income countries. METHODS During 2008-2010, we conducted a prospective cohort study and followed ~1,800 Argentinian children aged ≤5 years to identify those children who were hospitalized or who ...

BACKGROUND Mental disorders represent a major contributor to disease burden worldwide. We sought to quantify the national economic burden of mental disorders in China. METHODS We used a prevalence-based, bottom-up approach to estimate the economic costs of mental disorders in 2005-2013 in China. Prevalence data were derived from a national survey. Cost data were derived from the electronic he...