The coumarin antibiotic coumermycin A(1) contains at least eight methyl groups, presumably derived from S-adenosylmethionine. Two putative methyltransferase genes, couO and couP, of the coumermycin A(1) biosynthetic gene cluster were inactivated by in-frame deletion. In the resulting mutants, coumermycin A(1) production was abolished. New coumermycin derivatives were accumulated instead, and we...

Parallel systems are limited by the high costs of communication and synchronization. Exploiting commutativity has historically been a fruitful avenue to reduce traffic and serialization. This is because commutative operations produce the same final result regardless of the order they are performed in, and therefore can be processed concurrently and without communication. Unfortunately, software...

Why do coups happen and how can state leaders affect their likelihood? Existing research focuses on structural factors as well “coup-proofing” drivers of coup risk. I argue that the literature misses an important alternative avenue by which likelihood militaries remove them from office: adding or removing military officers government. When bring into government, they signal to there is a peacef...

In this issue of Blood, Kang and colleagues describe a molecular signaling network involving Notch, COUP-TFII, and Prox-1, along with other supporting molecules, that regulates the specification and maintenance of lymphatic endothelial cells.

The embryonic diaphragm comprises four major structural components derived from the transverse septum, the dorsal foregut mesentery, the pleuroperitoneal folds (PPFs), and the body wall. In this study, the appearance of PPFs and related factors were investigated using light microscopy of horizontal sections of rat fetuses from embryonic day 12 to 13. In rat fetuses, the sign of PPF projection w...

VOUZZAVEDIBISAR Fantaisie Edmond Bianco Quand je tirais le dernier bord, mon petit voilier s'approcha lentement de la côte, je donnais un petit coup de barre pour la longer en cherchant où aborder. Et en même temps je lâchais le foc et la grand'voile. La terre à une dizaine de mètres par trois mètres de fond, une étroite plage de sable, mais aussi pas mal de petits rochers, je ne pouvais aborde...

Linear scleroderma "en coup de sabre" is a subset of localized scleroderma with band-like sclerotic lesions typically involving the fronto-parietal regions of the scalp. Patients often present with neurologic symptoms. On imaging, patients may have lesions in the cerebrum ipsilateral to the scalp abnormality. Infratentorial lesions and other lesions not closely associated with the overlying sca...

Previous research has shown that good looks, particularly being deemed attractive or competent-looking, can provide an electoral advantage. There is also evidence to support the notion that more dominant looks are associated with military success. To date, there has been little research into the effect of looks on political leadership success in a non-democratic setting. This project explores t...

Conventional wisdom holds that high levels of system support serve as an attitudinal barrier to democratic breakdown. In unconsolidated democracies, however, where democratic norms are regularly violated, the authors hypothesize that a healthy dose of political skepticism toward the political system, neither extreme rejection nor uncritical support of the system, would be associated with greate...

BACKGROUND Hemifacial atrophy (Parry-Romberg syndrome) is a relatively rare disease. The etiology of the disease is not clear. Some authors postulate its relation with limited scleroderma linearis. Linear scleroderma "en coup de sabre" is characterized by clinical presence of most commonly one-sided linear syndrome. In a number of patients, neurological affection is the medium of the disease. T...