نتایج جستجو برای: cox 2
تعداد نتایج: 2552374 فیلتر نتایج به سال:
Cyclooxygenase 2 (COX-2) inhibitors are promising antiangiogenic agents in several preclinical models. The aim of the present study was to evaluate the effect of selective COX-2 inhibitors on vascular endothelial growth factor (VEGF) production in vitro and angiogenesis and growth of pancreatic cancer in vivo, focusing on putative differences between COX-2-negative and COX-2-positive tumors. VE...
Background: Transitional Cell Carcinoma (TCC) is the most common type of urinary bladder cancer. Cyclooxygenase-2 (COX-2), a key enzyme in prostaglandins biosynthesis, has been introduced as a new candidate for targeted therapy in this cancer. In this study, we investigated the expression of COX-2 in urinary bladder TCCs and its relationship with clinicopathological parameters such as tumor gra...
Background MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation and survival of cells. Also, MIF binding to CD74 activates p38 signaling pathways that lead to positive effect on the expression of COX-2. The aim of this study was to evaluate the gene expression profile of MIF, CD74 and COX-2 in normal, ectopic and eutopic endometrium during menstrual cycle. The e...
Arthritis refers to different medical conditions associated with disorder of the primary structures that determine joint functions such as bones, cartilage and synovial membranes. Drug discovery and delivery to retard the degeneration of joint tissues are challenging. Current treatments of different arthritis involves administration of ideal non-steroidal anti-inflammatory drugs (NSAIDs) but ar...
بیماری بازگشت مواد اسیدی معده به مری (gastroesophageal reflux disease; gerd) از جمله بیماریهای شایع در ایران و جهان محسوب می شود. عوامل خطرزای ژنتیکی ( از جمله پلی مورفیسم a105g در ژن gst-p1 ) و محیطی (از جمله مصرف دخانیات وچاقی ) در ایجاد بیماری یاد شده موثرند. داروی امپرازول از دسته داروهای بازدارنده پمپ هیدروژن جهت درمان بیماری بازگشت مواد اسیدی معده به مری بطور متداول تجویز می شود. آنزیم cy...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید