Acetylsalicylic acid (aspirin) is the drug most commonly self-administered to reduce inflammation, swelling, and pain. The established mechanism of action of aspirin is inhibition of the enzyme cyclo-oxygenase (COX). Once taken, aspirin is rapidly deacetylated to form salicylic acid, which may account, at least in part, for the therapeutic actions of aspirin. However, where tested, salicylic ac...

Spontaneously occurred canine mammary tumours (55) were treated with chemotherapy (Methotrexate), combination chemotherapy with COX-2 inhibitor (Meloxicam) and by surgical therapy. In chemotherapy groups Hb and TEC values reduced significantly (P<0.05) from the base line value at 3rd week of therapy. Histologically, benign and malignant mixed mammary tumours were predominant. Methotrexate and C...