The inflammatory microenvironment plays a critical role in the development and progression of malignancies. In the present study, we aimed to evaluate the prognostic value of lymphocyte-related inflammation and immune-based prognostic scores in patients with chordoma after radical resection, including the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ra...

Methods We performed a prospective observational cohort of MICU patients at the Brigham and Women’s Hospital from 2008-2010 [n=49]. The exposure of interest was 25(OH)D categorized a priori as deficiency (25(OH)D ≤ 15 ng/mL) and measured via competitive chemiluminescence immunoassay. Circulating plasma mitochondrial DNA (mt-DNA) were assessed by measuring copy number of the NADH dehydrogenase 1...

Method Two consecutive series of patients underwent arterial revascularization at two institutions from 2000-2010. In group A, 183 patients underwent CABG with non-sequential BIMA grafting, utilizing the RA for additional targets. In group B, 771 patients underwent solely sequential BIMA grafting in a Y-graft configuration. Patient differences were balanced using a propensity score developed fr...

In this article, we present nonparametric and semiparametric methods to analyze current status data subject to outcome misclassification. Our methods use nonparametric maximum likelihood estimation (NPMLE) to estimate the distribution function of the failure time when sensitivity and specificity are known and may vary among subgroups. A nonparametric test is proposed for the two sample hypothes...

Personalised medicine is replacing the one-drug-fits-all approach with many prognostic models incorporating biomarkers available for risk stratifying patients with breast cancer, such as the Nottingham Prognostic Index and Adjuvant! Online and more recently multiparameter assays, OncotypeDx and Mammaprint. Evidence of biomarkers having non-proportional effects have been emerging and therefore v...

Cox regression is commonly used to predict the outcome by the time to an event of interest and in addition, identify relevant features for survival analysis in cancer genomics. Due to the high-dimensionality of high-throughput genomic data, existing Cox models trained on any particular dataset usually generalize poorly to other independent datasets. In this paper, we propose a network-based Cox...

The National Immunization Survey-Flu (NIS-Flu) is an ongoing, national telephone survey of households with children in the United States used to measure influenza vaccination coverage. The data collected by NIS-Flu have similarities to data typically analyzed using survival analytic procedures. Estimates of vaccination coverage from the NIS-Flu survey are calculated using Kaplan-Meier survival ...

We describe a general multivariate, multilevel framework for continuous time survival analysis that includes joint modeling of survival time variables and continuous and categorical observed and latent variables. The proposed framework is implemented in the Mplus software package. The survival time variables are modeled with nonparametric or parametric proportional hazard distributions and incl...