The mRNA for Rvp.1 (rat ventral prostate) increases in abundance before gland involution after androgen deprivation. Rvp.1 is homologous to CPE-R, the high-affinity intestinal epithelial receptor for Clostridium perfringens enterotoxin (CPE), and is sufficient to mediate CPE binding and trigger subsequent toxin-mediated cytolysis. Rvp.1 (claudin-3) and CPE-R (claudin-4) are members of a larger ...

The choroid plexus epithelium (CPE) secretes the major fraction of the cerebrospinal fluid (CSF). The Na(+)-HCO(3)(-) transporter Ncbe/Nbcn2 in the basolateral membrane of CPE cells is important for Na(+)-dependent pH(i) increases and probably for CSF secretion. In the current study, the anion transport inhibitor DIDS had no effect on the residual pH(i) recovery in acidified CPE from Ncbe/Nbcn2...

Clostridium perfringens is a major cause of food poisoning (FP) in developed countries. C. perfringens isolates usually induce the gastrointestinal symptoms of this FP by producing an enterotoxin that is encoded by a chromosomal (cpe) gene. Those typical FP strains also produce spores that are extremely resistant to food preservation approaches such as heating and chemical preservatives. This r...

Tumor metastasis of epithelium-derived tumors is the major cause of death from malignant tumors. Overexpression of claudin is observed frequently in malignant tumors. However, claudin-targeting antimetastasis therapy has never been investigated. We previously prepared a claudin-4-targeting antitumor molecule that consisted of the C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE...

34 35 Coupling parameter-estimation (CPE) that uses observations in a medium to 36 estimate the parameters in other media may increase the coherence and consistence of 37 estimated parameters in a coupled system, through the uses of co-varying relationship 38 between variables residing in different media. However, accurately evaluating the 39 strength of co-varying of different media is usually...

Collin, Gayle B., Terry P. Maddatu, Śaunak Sen, and Jürgen K. Naggert. Genetic modifiers interact with Cpe to affect body weight, adiposity, and hyperglycemia. Physiol Genomics 22: 182–190, 2005. First published May 3, 2005; 10.1152/physiolgenomics.00208.2003.— Obesity and Type II diabetes are complex diseases in the human population. The existence of a large number of contributing loci and gen...

We investigated the potential superantigenic properties of Clostridium perfringens enterotoxin (CPE) on human peripheral blood mononuclear cells (PBMC). In contrast to the findings of a previous report (P. Bowness, P. A. H. Moss, H. Tranter, J. I. Bell, and A. J. McMichael, J. Exp. Med. 176:893-896, 1992), two different, biologically active preparations of CPE had no mitogenic effects on PBMC. ...

1. Eighth IEEE International Conference Grid 2007. Austin, TX, 19–21 September 2007. Available at: http://www.grid2007.org/. 2. Carroll TE, Grosu D. Formation of virtual organizations in grids: A game-theoretic approach. DOI: 10.1002/cpe.1369. 3. Macias M, Rana OF, Smith G, Guitart J, Torres J. Maximising revenue in grid markets using an economically enhanced resource manager. DOI: 10.1002/cpe....

Claudin, a tight junction integral membrane protein and a family of proteins, forms the actual sealing element of the tight junction. There are more than 20 members of the claudin family with different tissue-specific expression and barrier functions. Thus, a family of claudin may be a target for modifying the absorption of drugs. Here, we examined whether modulation of claudin could be used to...

A novel electronic cell sensor array technology, the real-time cell analysis (RTCA) system, was developed to monitor cell events. Unlike the conventional methods labeling the target cells with fluorescence, luminescence, or light absorption, the RTCA system allows for label-free detection of cell processes directly without the incorporation of labels. Here, we used this new format to measure th...