The pattern of congenital oral and craniofacial anomalies (CFAs) in the Kenyan population remains unknown. The objective of this study was to describe the pattern of occurrence of CFAs at two hospitals in Nairobi. A descriptive cross-sectional study at the Kenyatta National Hospital and Pumwani Maternity Hospital was carried out from November 2006 to March 2007. Mothers who delivered at the hos...

: http://p p://pubs.as The problems with feeding and swallowing that occur as a result of clefts and craniofacial anomalies range in severity. The extent of clefting, as well as other structural, airway, and neurologic issues, are factors that contribute to potential difficulty with oral feeding mechanics and with the integrity of airway protection during swallowing. Oral motor dysfunction in c...

background and aim: it is well - known that sex hormones regulate bone metabolism. sex steroids increase osteoblasts activities and affect growth, remodeling and bone homeostasis. the aim of this study was to examine the effects of sex hormones deficiency on craniofacial growth in rats. methods & materials: fifty, thirty–day–old wistar rats comprised the sample in this experimental study. 25 ma...

now-a-days truncus arteriosus has been known as “common arterial trunk” (cat) and is an uncommon congenital cardiac defect presenting in about 1-3% congenital heart disease. environmental and genetic factors effects on incidence of cat and other conotruncal anomalies. the majority patients with cat and 22q11 deletion have other anomalies such as hypoplasia or aplasia of the thymus or parath...

Goldenhar syndrome is a well-known condition featuring the following triad of anomalies: ocular abnormalities, microtia and vertebral anomalies. This syndrome involves structures arising from the first and second branchial arches. Craniofacial anomalies, including mandibular, zygomatic and/or maxillary hypoplasias are found in 50% of patients with Goldenhar syndrome. Patients with this syndrome...

The authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they suggest either genetically or epigene...

Derivative 22 [der(22)] syndrome is a rare disorder associated with multiple congenital anomalies including pre-auricular skin tags or pits, conotruncal heart defects, and profound mental retardation. Der(22)t(11;22) is one of the causes of supernumerary chromosome markers (mar) in humans. We present a boy with developmental delay and multiple anomalies consistent with the supernumerary der(22)...

Fetal hydantoin syndrome is a rare disorder that is believed to be caused by exposure of a fetus to the anticonvulsant drug phenytoin. The classic features of fetal hydantoin syndrome include craniofacial anomalies, prenatal and postnatal growth deficiencies, underdeveloped nails of the fingers and toes, and mental retardation. Less frequently observed anomalies include cleft lip and palate, mi...

The aim of the present study was to examine whether a putative relationship exists between the Class II division 2 craniofacial type and congenital anomalies of the dentition, such as missing teeth, peg-shaped laterals, transpositions, supernumerary teeth and canine impactions. Two hundred and sixty-seven untreated patients with Class II division 2 malocclusion were examined. The results show t...

Birth defects occur in nearly 5% of all live births and are the major cause of infant mortality and morbidity. Despite the recent progress in molecular and developmental biology, the underlying genetic etiology of most congenital anomalies remains unknown. Heterozygous deletion of the 22q11.2 locus results in the most common human genetic deletion syndrome, known as DiGeorge syndrome, and has s...