BACKGROUND Rapid local drug clearance of antimicrobials is a major drawback for the treatment of chronic periodontitis. In the study reported here, minocycline-loaded poly(ethylene glycol)-poly(lactic acid) nanoparticles were prepared and administered locally for long drug retention and enhanced treatment of periodontitis in dogs. METHODS Biodegradable poly(ethylene glycol)-poly(lactic acid) ...

1. This study investigated how the size of crevices might affect their effectiveness as refuges for diatom-dominated algal assemblages from the grazing minnow Campostoma anomalum. 2. Crevice size was manipulated by making fired-clay substrates, using moulds to produce eight substrates with pits from 1.17 to 22.0 mm diameter. Non-pitted clay-stones and limestone were also tested. Cages were used...

Allegheny Ludlum Type 316Ti (UNS S31635) is a titanium stabilized version of Type 316 molybdenum-bearing austenitic stainless steel. It is also known as DIN/EN designation No. 1.4571. The Type 316 alloys are more resistant to general corrosion and pitting/crevice corrosion than the conventional chromium-nickel austenitic stainless steels such as Type 304. They also offer higher creep, stress-ru...

The three-dimensional conformation of yeast cytochrome c peroxidase has been determined from a 2.5 A electron density map computed with phases obtained from two isomorphous mercury derivatives. Partial sequence information that has recently become available aided in completion of the tracing of the polypeptide backbone, confirmed the presence of a proximal histidine heme ligand and aided in ide...