The effects of aqueous-ethanolic extracts of Crocus sativus (Iridaceae) on muscarinic receptors were examined on tracheal chains of guinea pigs. The effects of three concentrations of aqueous-ethanolic extract, safranal, atropine and saline on muscarinic receptors were tested (n=8). The EC50 (effective concentration of methacoline causing 50% of maximum response) obtained in the presence of atr...

introduction: the cholinergic system plays an important role in learning and memory. administration of either extracts of crocus sativus (saffron) or its constituent, crocin, reduced ethanol-induced memory impairment. based on the above findings, we investigated the effect of crocin in antagonizing spatial learning and memory impairment induced by scopolamine, a cholinergic receptor antagonist,...

Since cancer is the most common cause of death in the world population, the possibility that readily available natural substances from plants, vegetables, herbs, and spices may be beneficial in the prevention of cancer warrants closer examination. Saffron in filaments is the dried, dark red stigmata of Crocus sativus L. flowers and it is used as a spice, food colorant, and a drug in medicine. A...

From ancient times, saffron dried stigmas of Crocus sativus L. is widely used as a drug against different human diseases. In the beginning of 1990 ́s scientific literature reported for the first time the antitumor activity of saffron. During the last decade different laboratories of the world (including ours) have accumulated sufficient scientific evidence to suggest that saffron, and its main i...

Introduction: The cholinergic system plays an important role in learning and memory. Administration of either extracts of Crocus Sativus (Saffron) or its constituent, crocin, reduced ethanol-induced memory impairment. Based on the above findings, we investigated the effect of crocin in antagonizing spatial learning and memory impairment induced by scopolamine, a cholinergic receptor antagoni...