Specific arrest of neutrophils in venules is central to their rapid accumulation during local inflammatory responses. Initial neutrophil rolling on endothelium is mediated by leukocyte L-selectin and the inducible vascular adhesion proteins P- and E-selectin. This rolling is a prerequisite for endothelial-dependent neutrophil arrest. Here we describe rolling of neutrophils on the surface of pre...

The paper addresses dynamic and control issues related to a dynamical model called the classical shimmying wheel. The classical shimmying wheel models the rolling dynamics of many physical rolling systems such as aircraft nose wheels, motorcycles, automotive systems and tractor{ trailer systems. Such system can exhibit undesirable unstable rolling motion, i.e. shimmying, which can often lead to...

Different from the cross-section profile defects caused by uneven roll wear or external forces during hot finishing rolling, edge warping defect often occurs and has special local characteristics. However, cause control method of are still unclear. By superposition calculating shape, it is found that high-order comprehensive gap contour formed bathtub-shaped thermal parabolic original shape mai...

Production of thin steel strips with 0.18-0.26 mm thickness is about 0.75 of annual production of the two stand reversing cold mill, while its efficiency is 60%. This is due to the fact that after montaging the grinded work rolls, rolling thin steel strips (with thicknesses less than 0.18 millimeters) is unavailable. Initially, unsuitable surface roughness, the friction between rolls and the st...

in this article, the experiments carried out on making, rolling and measuring the physical and mechanical properties of iow - carbon ferritic steels of various phosphorus contents ranging from 0.0 11 to 0.085 percent are discussed • the results indicate that possibility of performance of both cold and hot rolling operations up to at least one fourth of the initial thickness exists through a seq...

The rolling motion of a rigid cylinder on an inclined flat viscous surface is investigated and the nonlinear resistance force against rolling, FR(v), is derived. For small velocities FR(v) increases with velocity due to increasing deformation rate of the surface material. For larger velocity it decreases with velocity due to decreasing contact area between the rolling cylinder and the deformed ...

This problem was suggested by Bradley Klee. For the related case of one cylinder rolling inside another, see [1]. When one cylinder is directly above the other, we define the line of contact of the lower cylinder, 1, with the horizontal plane to be the z-axis, at x = y = 0. Then, the condition of rolling without slipping for the lower cylinder is that when it has rolled (positive) distance x1, ...

L-selectin is a calcium-dependent lectin on leukocytes mediating leukocyte rolling in high endothelial venules and inflamed microvessels. Many selectin ligands require modification of glycoproteins by leukocyte core2 beta1,6-N-acetylglucosaminyltransferase (Core2GlcNAcT-I). To test the role of Core2GlcNAcT-I for L-selectin ligand biosynthesis, we investigated leukocyte rolling in venules of unt...

OBJECTIVES P-selectin binding to P-selectin glycoprotein ligand-1 (PSGL)-1 mediates leukocyte rolling under conditions of inflammation and injury. The aims of this study were to develop an efficient, high temporal resolution model for direct simulation of leukocyte rolling and conduct a study of load-bearing bonds using the model. MATERIALS AND METHODS A stochastic pi-calculus-driven event-tr...

The purpose of this study was to compare the difference between the rolling toothbrushing motion a newly designed brushing machine and three subjects who were skilled in the rolling toothbrushing technique. The evaluation of the distortion curves of the rolling toothbrushing motion recorded by a tri-axial strain gauge attached to the shank of the toothbrush indicate the newly designed brushing ...