TDMQ chelators have been designed as drug-candidates for the regulation of copper homeostasis and reduction oxidative stress in brain Alzheimer's patients. To achieve suitable biological properties high Cu(II) selectivity a zinc-rich medium, ligands must meet critical coordination chemistry requirements related to structures CuII-TDMQ complexes. The correlation between X-ray diffraction Cu- Zn-...

Reductionism is the idea that all of the complex and apparently disparate things we observe in the world can be explained in terms of universal principles governing their common ultimate constituents: that physics is the theory of everything. Antireductionism comes in two varieties: epistemological and ontological. Epistemological antireductionism holds that, given our finite mental capacities,...

Use of preformed metal-organic polyhedra (MOPs) as supermolecular building blocks (SBBs) for the synthesis frameworks (MOFs) remains underexplored due to lack robust functionalized MOPs. Herein we report use polycarboxylate cuboctahedral RhII-MOPs constructing highly-connected MOFs. Cuboctahedral MOPs were with carboxylic acid groups on their 12 vertices or 24 edges through coordinative covalen...

The reaction of one equivalent of [n-Bu4N]2[Ni(opboR2)] with two equivalents of [Cu(pmdta)(X)2] afforded the heterotrinuclear CuIINiIICuII containing bis(oxamidato) type complexes [Cu2Ni(opboR2)(pmdta)2]X2 (R = Me, X = NO3- (1); R = Et, X = ClO4- (2); R = n-Pr, X = NO3- (3); opboR2 = o-phenylenebis(NR-substituted oxamidato); pmdta = N,N,N',N",N"-pentamethyldiethylenetriamine). The identities of...

Genital gender affirming surgery (GAS) involves reconstruction of the genitals to match a patient's identified sex. The use of hair-bearing flaps in this procedure may result in postoperative intra-vaginal and intra-urethral hair growth and associated complications, including lower satisfaction with genital GAS. Despite the significant increase in genital GAS within the past 50 years, there is ...

We present the case of a symptomatic anterior elbow cyst supposedly due to repeated (exertional) trauma. Instead of the usual open excision, arthroscopic excision was performed using a Wissinger rod through an additional anterolateral portal for distraction. Histopathology confirmed the lesion to be a ganglion. MRI 12 months postoperatively showed no recurrence.

An environmentally benign, fast and convenient protocol has been developed for the Michael addition of 1,3-dicarbonyl compounds to β-nitroalkenes in good to excellent yields by a grinding method under catalyst- and solvent-free conditions.