The membrane potentials and resistances of giant mitochondria from mice fed cuprizone have been studied. They were found to correspond approx. 10-20 mV, positive inside, and 2 M omega, respectively. These properties were found to be independent of the metabolic state. The microelectrodes were in the inner mitochondrial space since (a) the potentials in the presence of valinomycin depended on th...

sVeto S, Acs P, Bauer J, Lassmann H, Berente Z, Sumegi B, Komoly S, Gallyas F Jr,Illes Z, 2010. Inhibiting poly(ADP-ribose) polymerase: a potential therapy againstoligodendrocyte death in multiple sclerosis. Clinical Immunology 135: S30-S30 Veto S, Acs P, Bauer J, Lassmann H, Berente Z, Sumegi B, Komoly S, Gallyas F Jr,Illes Z, 2010. Poly(ADP-ribose) polymerase (PARP) is activat...

and correlation with histology Laura Turati, Fulvio Baggi, Marco Moscatelli, Alfonso Mastropietro, Ileana Zucca, Alessandra Erbetta, Chiara Cordiglieri, Greta Brenna, Nicholas Dowell, Renato Mantegazza, Ludovico Minati, and Mara Cercignani Neuroimmunology and Neuromuscular Diseases Unit, Neurological Institute "Carlo Besta", Milan, Italy, Scientific Department, Neurological Institute "Carlo Bes...

An imbalance between remyelinating and demyelinating rates underlies degenerative processes in demyelinating diseases such as multiple sclerosis. An optimal therapeutic strategy would be to stimulate remyelination while limiting demyelination. Although accumulation of myelin debris impairs remyelination, the mechanisms regulating the clearance of such debris by mononuclear phagocytic cells are ...