αβ-tubulin dimers need to convert between a 'bent' conformation observed for free dimers in solution and a 'straight' conformation required for incorporation into the microtubule lattice. Here, we investigate the free energy landscape of αβ-tubulin using molecular dynamics simulations, emphasizing implications for models of assembly, and modulation of the conformational landscape by colchicine,...

Allogeneic hematopoietic stem cell transplantation is associated with several complications and risk factors, for example, graft versus host disease (GVHD), viral infections, relapse, and graft rejection. While high levels of CD3+ cells in grafts can contribute to GVHD, they also promote the graft versus leukemia (GVL) effect. Infusions of extra lymphocytes from the original stem cell donor can...

The mammalian T cell receptor (TCR) orchestrates immunity by responding to many billions of different ligands that it has never encountered before and cannot adapt to at the protein sequence level. This remarkable receptor exists in two main heterodimeric isoforms: αβ TCR and γδ TCR. The αβ TCR is expressed on the majority of peripheral T cells. Most αβ T cells recognize peptides, derived from ...

In psoriasis, an IL-17-mediated inflammatory skin disease, skin lesions resolve with therapy, but often recur in the same locations when therapy is discontinued. We propose that residual T cell populations in resolved psoriatic lesions represent the pathogenic T cells of origin in this disease. Utilizing high-throughput screening (HTS) of the T cell receptor (TCR) and immunostaining, we found t...

In this paper we obtain new lower bounds for the upper box dimension of αβ sets. As a corollary our main result, show that if α is not Liouville number and β number, then any set 1. We also use to results on affine embeddings self-similar

One of the most important prediction problems in finite population is the prediction of a linear function of characteristic values of a finite population. In this paper the admissibility of linear predictors of an arbitrary linear function of characteristic values in a finite population under reflected normal loss function is considered. Under the super-population model, we obtain the condition...

In this paper, at first, we introduce $alpha_{mu}$-admissible, $Z_mu$-contraction and  $N_{mu}$-contraction via simulation functions. We prove some new fixed point theorems for defined class of contractions   via $alpha$-admissible simulation mappings, as well. Our results  can be viewed as extension of the corresponding results in this area.  Moreover, some examples and an application to funct...

We study a non-anticommutative chiral non-singlet deformation of the N =(1, 1) abelian gauge multiplet in Euclidean harmonic superspace with a product ansatz for the deformation matrix, C (αβ) (ik) = c (αβ) b (ik). This choice allows us to obtain in closed form the gauge transformations and the unbroken N =(1, 0) supersymmetry transformations preserving the Wess-Zumino gauge, as well as the bos...

Hematopoietic stem cell transplantation is standard therapy for numerous hematological diseases. The use of haploidentical donors, sharing half of the HLA alleles with the recipient, has facilitated the use of this procedure as patients can rely on availability of a haploidentical donor within their family. Since HLA disparity increases the risk of graft-versus-host disease, T-cell depletion ha...