OBJECTIVES Myostatin, a negative regulator of muscle growth, is increased in hypertrophied and infarcted heart. However, the mechanism of regulation is not known. Mechanical stress is an important regulatory factor for cardiomyocyte growth. The aim of the study was to investigate the effect of cyclic stretch on the expression of myostatin gene in cardiomyocytes. METHODS Neonatal Wistar rat ca...

Void detection is challenging due to the complexity of near-surface materials and the limited resolution of geophysical methods. Although multichannel, high-frequency, surface-wave techniques can provide reliable shear (S)-wave velocities in different geological settings, they are not suitable for detecting voids directly based on anomalies of the S-wave velocity because of limitations on the r...

Mode I, quasi-static, steady state crack growth is analyzed for rate dependent materials under plane strain conditions in small scale yielding. The solid is characterized by an elastic-viscoplastic constitutive law and the plane ahead of the crack tip is embedded with a rate dependent fracture process zone. The macroscopic work of fracture of the material is computed as a function of the crack ...

The mechanical properties and damage behavior of amorphous polyethylene are investigated using Molecular Dynamics (MD) simulations. influence time, temperature, size scale, stress state extensively studied to gather insights into the complex nature glassy polymers related process void formation during dynamic loading conditions. Modified Embedded Atom Method (MEAM) is employed model interatomic...

Based on a laser diode, a 12 × 6 photodiode array sensor, and machine learning techniques, a new void fraction measurement method for gas-liquid two-phase flow in small channels is proposed. To overcome the influence of flow pattern on the void fraction measurement, the flow pattern of the two-phase flow is firstly identified by Fisher Discriminant Analysis (FDA). Then, according to the identif...

In rats no consistent change in the concentration of cyclic GMP or cyclic AMP concentration was found in the renal cortex between 2 hours and seven days after unilateral nephrectomy. In regenerating liver tissue, between 2 hours and seven days after removal of one-third of the liver, there were no consistent changes in cyclic GMP concentrations, but cyclic AMP concentrations were higher than in...

an analytical nonlinear stress-strain model and a microscopic damage index for confined and unconfined concretes together with a macroscopic damage index for reinforced concrete (rc) structures under cyclic loading are proposed. in order to eliminate the problem of scale effect, an adjustable finite element computer program was generated to simulate rc structures subjected to cyclic loading. by...

Porosity is postulated to be one of the reasons for the low efficiency of tin sulfide-based devices. This work is a preliminary investigation of the effects of two film growth parameters deposition rate and substrate temperature on porosity. We employ the focused ion beam tomography technique to characterize and quantify porosity in tin sulfide thin films. We then generate 3D reconstructions of...

shear modulus and damping ratio are important input parameters in dynamic analysis. a series of resonant column tests was carried out on pure clays and sand-clay mixtures prepared at different densities to investigate the effects of aggregate content, confining stress, void ratio and clay plasticity on the maximum shear modulus and minimum damping ratio. test results revealed an increase in the...