Rocha e Silva and Rosenthal (1) have reported that the exudates from burnt rat skin contain histamine, bradykinin, adenosine derivatives and possibly serotonin and other as yet unidentified pharmacologically active and toxic substances. Hodson (2) has reported the peripheral antiserotonin activity of B.W. 501 C 67 (α-anilino-N-2-m-chlorophenoxypropyl acetamidine hydrochloride monohydrate)...

Mitragynine is a major alkaloidal constituent of young leaves of Mitragyna speciosa Korth, that is known to exhibit narcotic-like activity. In this study, we investigated the roles of central monoaminergic systems in the antinociceptive action of mitragynine by means of the tail-pinch and hot-plate tests in mice. Mitragynine (1.0-10 micrograms) injected i.c.v. exerted a dose-dependent antinocic...

Abstract This study establishes a method for rapid detection of clonidine and cyproheptadine in foods animal origin. In order to obtain the best method, capillary zone electrophoresis (CZE), large volume sample stacking (LVSS), sweeping-micellar electrokinetic chromatography (sweeping-MEKC) were used respectively. The limits (LODs) by LVSS-CZE 0.028 ?g mL ?1 0.034 , those sweeping-MEKC 0.023 0....

Elevated levels of serotonin (5-hydroxytryptamine, 5-HT) are observed in the serum of asthmatics. Herein, we demonstrate that 5-HT functions independently as an eosinophil chemoattractant that acts additively with eotaxin. 5-HT2A receptor antagonists (including MDL-100907 and cyproheptadine (CYP)) were found to inhibit 5-HT-induced, but not eotaxin-induced migration. Intravital microscopy studi...

While the role of 5-hydroxytryptamine (5-HT, serotonin) in the nociceptive processing has been widely investigated in the central nervous system, information regarding its role in peripheral tissues is still lacking. Noteworthy, 5-HT induces phenotypic changes of nociceptors and peripheral injection induces pain in humans and nociceptive response in rodents. However, local receptors involved in...

The effect of endotoxin on the body temperature of mice was studied in animals housed without bedding at an environmental temperature of 15 C. Rectal temperatures were measured during the initial 3 to 5 hr of exposure. Doses of endotoxin ranging from 0.01 to 1 ld(50), as determined for mice maintained at 25 C, produce a hypothermia in proportion to dose. Concurrent injection of tryptophan magni...

Background: Previous reports suggest flavonoids as potent analgesic compounds. Objectives: Based on these observations, the present study investigated anti-nociceptive action of troxerutin and neural interactions with opioidergic, serotoninergic, nitrergic systems in mice. Methods: A total 340 male mice were randomly divided into 2 categories. Each category included four experiments groups. In ...